Itm2b (integral membrane protein 2B) - Rat Genome Database

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Gene: Itm2b (integral membrane protein 2B) Rattus norvegicus
Analyze
Symbol: Itm2b
Name: integral membrane protein 2B
RGD ID: 620727
Description: Predicted to enable ATP binding activity and amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in Golgi-associated vesicle membrane and extracellular space. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bri; imBRI2; immature BRI2; MGC94644; transmembrane protein BRI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81554,955,549 - 54,978,455 (-)NCBIGRCr8
mRatBN7.21548,545,998 - 48,568,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,546,001 - 48,568,917 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1552,686,973 - 52,709,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,798,548 - 53,821,416 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,643,525 - 50,666,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,254,703 - 55,277,713 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,254,706 - 55,277,713 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01558,977,916 - 59,000,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41554,005,134 - 54,028,036 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11554,020,916 - 54,021,022 (-)NCBI
Celera1548,194,879 - 48,217,785 (-)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
Deoxycorticosterone acetate  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
flutamide  (EXP)
hydrogen peroxide  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
mercury dibromide  (ISO)
methidathion  (ISO)
methimazole  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chloride  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrogallol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
amyloid-beta binding  (IBA,IEA,ISO)
ATP binding  (IEA,ISO)
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Fleischer A, etal., Oncogene 2002 May 9;21(20):3181-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia. Holton JL, etal., Am J Pathol 2001 Feb;158(2):515-26.
4. Identification and characterization of the BRI2 interactome in the brain. Martins F, etal., Sci Rep. 2018 Feb 23;8(1):3548. doi: 10.1038/s41598-018-21453-3.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10526337   PMID:10679242   PMID:12477932   PMID:15489334   PMID:16027166   PMID:17965014   PMID:18097506   PMID:18524908   PMID:19056867   PMID:19114711   PMID:19199708   PMID:19849849  
PMID:19946888   PMID:22194595   PMID:22871113   PMID:23376485   PMID:23533145   PMID:26515131   PMID:28176357   PMID:34416235  


Genomics

Comparative Map Data
Itm2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81554,955,549 - 54,978,455 (-)NCBIGRCr8
mRatBN7.21548,545,998 - 48,568,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,546,001 - 48,568,917 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1552,686,973 - 52,709,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,798,548 - 53,821,416 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,643,525 - 50,666,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,254,703 - 55,277,713 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,254,706 - 55,277,713 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01558,977,916 - 59,000,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41554,005,134 - 54,028,036 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11554,020,916 - 54,021,022 (-)NCBI
Celera1548,194,879 - 48,217,785 (-)NCBICelera
Cytogenetic Map15q11NCBI
ITM2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,233,206 - 48,270,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1348,232,612 - 48,270,357 (+)EnsemblGRCh38hg38GRCh38
GRCh371348,807,342 - 48,844,493 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,705,309 - 47,734,228 (+)NCBINCBI36Build 36hg18NCBI36
Build 341347,705,306 - 47,734,226NCBI
Celera1329,861,986 - 29,890,942 (+)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1329,599,469 - 29,628,426 (+)NCBIHuRef
CHM1_11348,774,975 - 48,803,938 (+)NCBICHM1_1
T2T-CHM13v2.01347,453,540 - 47,490,689 (+)NCBIT2T-CHM13v2.0
Itm2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,599,666 - 73,622,729 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1473,599,666 - 73,622,729 (-)EnsemblGRCm39 Ensembl
GRCm381473,362,226 - 73,385,289 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,362,226 - 73,385,289 (-)EnsemblGRCm38mm10GRCm38
MGSCv371473,762,038 - 73,785,078 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361472,096,386 - 72,119,426 (-)NCBIMGSCv36mm8
Celera1470,882,475 - 70,905,515 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.88NCBI
Itm2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554311,928,706 - 1,937,238 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554311,928,706 - 1,935,010 (+)NCBIChiLan1.0ChiLan1.0
ITM2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21449,682,894 - 49,711,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11348,334,085 - 48,362,808 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01329,383,318 - 29,412,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11348,105,762 - 48,113,838 (+)NCBIpanpan1.1PanPan1.1panPan2
ITM2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,255,139 - 3,261,440 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,255,631 - 3,261,433 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,283,458 - 3,311,398 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0223,368,494 - 3,396,449 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl223,368,334 - 3,396,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1223,154,017 - 3,181,970 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0223,216,709 - 3,244,525 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,222,094 - 3,250,064 (-)NCBIUU_Cfam_GSD_1.0
Itm2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945158,051,536 - 158,073,617 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365651,535,779 - 1,557,013 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365651,535,570 - 1,557,667 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITM2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,349,134 - 19,377,917 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,349,088 - 19,377,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,802,615 - 19,874,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITM2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1326,149,429 - 26,178,172 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl326,149,379 - 26,177,622 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605717,730,923 - 17,759,981 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itm2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247486,598,984 - 6,622,796 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247486,598,986 - 6,622,679 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itm2b
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:91
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000023037
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat

Markers in Region
RH142637  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,564,033 - 48,564,155 (+)MAPPERmRatBN7.2
Rnor_6.01555,272,842 - 55,272,963NCBIRnor6.0
Rnor_5.01558,996,055 - 58,996,176UniSTSRnor5.0
RGSC_v3.41554,023,166 - 54,023,287UniSTSRGSC3.4
Celera1548,212,915 - 48,213,036UniSTS
Cytogenetic Map15p11UniSTS
RH129302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,546,649 - 48,546,829 (+)MAPPERmRatBN7.2
Rnor_6.01555,255,355 - 55,255,534NCBIRnor6.0
Rnor_5.01558,978,568 - 58,978,747UniSTSRnor5.0
RGSC_v3.41554,005,786 - 54,005,965UniSTSRGSC3.4
Celera1548,195,531 - 48,195,710UniSTS
Cytogenetic Map15p11UniSTS
RH142259  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,546,673 - 48,546,831 (+)MAPPERmRatBN7.2
Rnor_6.01555,255,379 - 55,255,536NCBIRnor6.0
Rnor_5.01558,978,592 - 58,978,749UniSTSRnor5.0
RGSC_v3.41554,005,810 - 54,005,967UniSTSRGSC3.4
Celera1548,195,555 - 48,195,712UniSTS
Cytogenetic Map15p11UniSTS
RH141160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,546,414 - 48,546,597 (+)MAPPERmRatBN7.2
Rnor_6.01555,255,120 - 55,255,302NCBIRnor6.0
Rnor_5.01558,978,333 - 58,978,515UniSTSRnor5.0
RGSC_v3.41554,005,551 - 54,005,733UniSTSRGSC3.4
Celera1548,195,296 - 48,195,478UniSTS
Cytogenetic Map15p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001006963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF034245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023037   ⟹   ENSRNOP00000023037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1548,546,004 - 48,568,917 (-)Ensembl
Rnor_6.0 Ensembl1555,254,706 - 55,277,713 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106965   ⟹   ENSRNOP00000080311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1548,546,001 - 48,561,312 (-)Ensembl
RefSeq Acc Id: NM_001006963   ⟹   NP_001006964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81554,955,549 - 54,978,455 (-)NCBI
mRatBN7.21548,545,998 - 48,568,904 (-)NCBI
Rnor_6.01555,254,703 - 55,277,713 (-)NCBI
Rnor_5.01558,977,916 - 59,000,926 (-)NCBI
RGSC_v3.41554,005,134 - 54,028,036 (-)RGD
Celera1548,194,879 - 48,217,785 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001006964 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83735 (Get FASTA)   NCBI Sequence Viewer  
  EDM02268 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023037.3
  ENSRNOP00000080311.1
  ENSRNOP00055020634
  ENSRNOP00060025980
  ENSRNOP00065010786
GenBank Protein Q5XIE8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001006964   ⟸   NM_001006963
- UniProtKB: Q5XIE8 (UniProtKB/Swiss-Prot),   A0A8I5ZPB1 (UniProtKB/TrEMBL),   A6HTQ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023037   ⟸   ENSRNOT00000023037
Ensembl Acc Id: ENSRNOP00000080311   ⟸   ENSRNOT00000106965
Protein Domains
BRICHOS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIE8-F1-model_v2 AlphaFold Q5XIE8 1-266 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699823
Promoter ID:EPDNEW_R10347
Type:initiation region
Name:Itm2b_1
Description:integral membrane protein 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01555,277,709 - 55,277,769EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620727 AgrOrtholog
BioCyc Gene G2FUF-13164 BioCyc
Ensembl Genes ENSRNOG00000016271 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055014728 UniProtKB/Swiss-Prot
  ENSRNOG00060018579 UniProtKB/Swiss-Prot
  ENSRNOG00065009003 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023037.6 UniProtKB/Swiss-Prot
  ENSRNOT00000106965.1 UniProtKB/TrEMBL
  ENSRNOT00055025233 UniProtKB/Swiss-Prot
  ENSRNOT00060031957 UniProtKB/Swiss-Prot
  ENSRNOT00065014391 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191589 IMAGE-MGC_LOAD
InterPro BRICHOS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ITM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290364 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94644 IMAGE-MGC_LOAD
NCBI Gene Itm2b ENTREZGENE
PANTHER INTEGRAL MEMBRANE PROTEIN 2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10962 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itm2b PhenoGen
PROSITE BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016271 RatGTEx
  ENSRNOG00055014728 RatGTEx
  ENSRNOG00060018579 RatGTEx
  ENSRNOG00065009003 RatGTEx
SMART BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPB1 ENTREZGENE, UniProtKB/TrEMBL
  A6HTQ5 ENTREZGENE, UniProtKB/TrEMBL
  ITM2B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Itm2b  integral membrane protein 2B      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Itm2b  integral membrane protein 2B      Symbol and Name status set to provisional 70820 PROVISIONAL