Adam18 (ADAM metallopeptidase domain 18) - Rat Genome Database

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Gene: Adam18 (ADAM metallopeptidase domain 18) Rattus norvegicus
Analyze
Symbol: Adam18
Name: ADAM metallopeptidase domain 18
RGD ID: 620405
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in cell differentiation; proteolysis; and spermatogenesis. Predicted to be located in membrane. Orthologous to human ADAM18 (ADAM metallopeptidase domain 18); INTERACTS WITH acrylamide; ammonium chloride; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 18; a disintegrin and metalloproteinase domain 18; ADAM 18; disintegrin and metalloproteinase domain-containing protein 18; tMDC III; tMDCIII; transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,054,974 - 74,127,861 (+)NCBIGRCr8
mRatBN7.21667,352,360 - 67,425,820 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,352,416 - 67,425,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,629,559 - 72,702,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01676,035,233 - 76,106,789 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,284,611 - 71,355,984 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01672,139,100 - 72,210,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,139,063 - 72,210,900 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,786,188 - 71,860,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,782,433 - 71,860,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,811,509 - 71,861,178 (+)NCBI
Celera1665,253,599 - 65,324,726 (+)NCBICelera
Cytogenetic Map16q12.4-q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract. Frayne J, etal., Mol Hum Reprod 1998 May;4(5):429-37.
2. Human tMDC III: a sperm protein with a potential role in oocyte recognition. Frayne J, etal., Mol Hum Reprod 2002 Sep;8(9):817-22.
3. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, etal., Mol Reprod Dev 1997 Oct;48(2):159-67.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Adam18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,054,974 - 74,127,861 (+)NCBIGRCr8
mRatBN7.21667,352,360 - 67,425,820 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,352,416 - 67,425,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,629,559 - 72,702,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01676,035,233 - 76,106,789 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,284,611 - 71,355,984 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01672,139,100 - 72,210,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,139,063 - 72,210,900 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,786,188 - 71,860,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,782,433 - 71,860,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,811,509 - 71,861,178 (+)NCBI
Celera1665,253,599 - 65,324,726 (+)NCBICelera
Cytogenetic Map16q12.4-q12.5NCBI
ADAM18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,584,568 - 39,730,065 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,584,489 - 39,730,065 (+)EnsemblGRCh38hg38GRCh38
GRCh37839,442,087 - 39,587,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,561,299 - 39,706,644 (+)NCBINCBI36Build 36hg18NCBI36
Build 34839,561,298 - 39,706,644NCBI
Celera838,393,916 - 38,539,440 (+)NCBICelera
Cytogenetic Map8p11.22NCBI
HuRef837,975,660 - 38,121,135 (+)NCBIHuRef
CHM1_1839,489,004 - 39,634,486 (+)NCBICHM1_1
T2T-CHM13v2.0839,861,797 - 40,007,263 (+)NCBIT2T-CHM13v2.0
Adam18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,092,262 - 25,164,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,092,262 - 25,164,771 (-)EnsemblGRCm39 Ensembl
GRCm38824,602,246 - 24,674,755 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,602,246 - 24,674,755 (-)EnsemblGRCm38mm10GRCm38
MGSCv37825,712,718 - 25,785,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,067,791 - 26,140,298 (-)NCBIMGSCv36mm8
Celera826,087,026 - 26,155,195 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map812.82NCBI
Adam18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555363,012,888 - 3,109,418 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555363,014,457 - 3,109,257 (-)NCBIChiLan1.0ChiLan1.0
ADAM18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11625,566,325 - 25,750,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1625,567,301 - 25,750,185 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1626,075,839 - 26,259,260 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01627,393,923 - 27,572,951 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11625,691,171 - 25,875,353 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01626,246,883 - 26,430,558 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01626,305,998 - 26,489,651 (+)NCBIUU_Cfam_GSD_1.0
Adam18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494348,635,487 - 48,772,589 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936843707,093 - 836,657 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936843805,614 - 836,657 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,166,119 - 9,233,952 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,178,152 - 9,233,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21710,940,383 - 10,995,690 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,600,595 - 37,743,772 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl837,601,156 - 37,743,650 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660524,187,395 - 4,334,713 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247804,054,259 - 4,186,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam18
777 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000023805
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 3 8 12 17 4 15 4 1 32 17 6 2 33 13

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001375316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_360576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023805   ⟹   ENSRNOP00000023805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,352,416 - 67,425,248 (+)Ensembl
Rnor_6.0 Ensembl1672,139,063 - 72,210,900 (+)Ensembl
RefSeq Acc Id: NM_001375316   ⟹   NP_001362245
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,055,025 - 74,127,858 (+)NCBI
mRatBN7.21667,352,416 - 67,425,248 (+)NCBI
RefSeq Acc Id: XM_039094794   ⟹   XP_038950722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,977 - 74,127,861 (+)NCBI
mRatBN7.21667,352,362 - 67,425,818 (+)NCBI
RefSeq Acc Id: XM_039094795   ⟹   XP_038950723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,974 - 74,117,853 (+)NCBI
mRatBN7.21667,352,360 - 67,415,255 (+)NCBI
RefSeq Acc Id: XM_039094796   ⟹   XP_038950724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,974 - 74,117,853 (+)NCBI
mRatBN7.21667,352,360 - 67,414,928 (+)NCBI
RefSeq Acc Id: XM_063275669   ⟹   XP_063131739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,981 - 74,117,853 (+)NCBI
RefSeq Acc Id: XM_063275670   ⟹   XP_063131740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,982 - 74,117,853 (+)NCBI
RefSeq Acc Id: XM_063275671   ⟹   XP_063131741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,994 - 74,127,861 (+)NCBI
RefSeq Acc Id: XR_005494666
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,974 - 74,127,861 (+)NCBI
mRatBN7.21667,352,360 - 67,425,820 (+)NCBI
RefSeq Acc Id: XR_010058312
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,981 - 74,127,861 (+)NCBI
RefSeq Acc Id: XR_010058313
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,975 - 74,127,861 (+)NCBI
RefSeq Acc Id: XR_010058314
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,974 - 74,127,861 (+)NCBI
RefSeq Acc Id: XR_010058315
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,982 - 74,127,861 (+)NCBI
RefSeq Acc Id: XR_010058316
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,054,982 - 74,127,861 (+)NCBI
Ensembl Acc Id: ENSRNOP00000023805   ⟸   ENSRNOT00000023805
RefSeq Acc Id: XP_038950723   ⟸   XM_039094795
- Peptide Label: isoform X1
- UniProtKB: F1LRY9 (UniProtKB/TrEMBL),   A6IW32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950724   ⟸   XM_039094796
- Peptide Label: isoform X3
- UniProtKB: A6IW32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950722   ⟸   XM_039094794
- Peptide Label: isoform X1
- UniProtKB: F1LRY9 (UniProtKB/TrEMBL),   A6IW32 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001362245   ⟸   NM_001375316
- Peptide Label: precursor
- UniProtKB: A6IW32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131739   ⟸   XM_063275669
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063131740   ⟸   XM_063275670
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063131741   ⟸   XM_063275671
- Peptide Label: isoform X5
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97776-F1-model_v2 AlphaFold P97776 1-445 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700182
Promoter ID:EPDNEW_R10701
Type:initiation region
Name:Adam18_1
Description:ADAM metallopeptidase domain 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01672,139,161 - 72,139,221EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620405 AgrOrtholog
BioCyc Gene G2FUF-10944 BioCyc
Ensembl Genes ENSRNOG00000017683 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023805.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene 57029 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam18 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017683 RatGTEx
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IW32 ENTREZGENE, UniProtKB/TrEMBL
  ADA18_RAT UniProtKB/Swiss-Prot
  F1LRY9 ENTREZGENE, UniProtKB/TrEMBL
  P97776 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adam18  ADAM metallopeptidase domain 18  Adam18  a disintegrin and metallopeptidase domain 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Adam18  a disintegrin and metallopeptidase domain 18    a disintegrin and metalloproteinase domain 18  Name updated 1299863 APPROVED
2002-08-07 Adam18  a disintegrin and metalloproteinase domain 18      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in spermatogenesis and fertilization. 724707
gene_product sperm surface membrane protein; a non catalytic metalloprotease-like protein 724707