Ighe (immunoglobulin heavy constant epsilon) - Rat Genome Database

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Gene: Ighe (immunoglobulin heavy constant epsilon) Rattus norvegicus
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Symbol: Ighe
Name: immunoglobulin heavy constant epsilon
RGD ID: 2880
Description: Predicted to enable MHC class II protein complex binding activity; immunoglobulin receptor binding activity; and peptide antigen binding activity. Predicted to be involved in several processes, including B cell activation; B cell mediated immunity; and leukocyte degranulation. Predicted to act upstream of or within several processes, including positive regulation of cytokine production; positive regulation of immune effector process; and signal release. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of IgE B cell receptor complex; MHC class II protein complex; and immunoglobulin complex, circulating. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia 1 and allergic rhinitis. Orthologous to human IGHE (immunoglobulin heavy constant epsilon) and IGHM (immunoglobulin heavy constant mu); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: gene
Previously known as: IGH2; immunoglobulin heavy chain (epsilon polypeptide)
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Iddm8  
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06138,066,728 - 138,068,606 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06147,059,437 - 147,061,209 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera6129,872,683 - 129,874,561 (-)NCBICelera
RGSC_v3.16138,265,953 - 138,270,304 (-)NCBI
Cytogenetic Map6q32NCBI



Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Correlation between genetic and cytogenetic maps of the rat. Andoh Y, etal., Mamm Genome 1998 Apr;9(4):287-93.
2. Novel Multiplexed Plasma Biomarker Panel Has Diagnostic and Prognostic Potential in Children With Hypertrophic Cardiomyopathy. Captur G, etal., Circ Genom Precis Med. 2024 Jun;17(3):e004448. doi: 10.1161/CIRCGEN.123.004448. Epub 2024 Jun 7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A rapidly evolving region in the immunoglobulin heavy chain loci of rat and mouse: postulated role of (dC-dA)n.(dG-dT)n sequences. Hellman L, etal., Gene 1988 Aug 15;68(1):93-100.
6. Synthesis of surface immunoglobulin E receptor in Xenopus oocytes by translation of mRNA from rat basophilic leukemia cells. Liu FT and Orida N, J Biol Chem. 1984 Sep 10;259(17):10649-52.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Mouse and rat IgE Cross-sensitization of mast cells and antigenic relationships. Prouvost-Danon A, etal., Immunology. 1975 Jul;29(1):151-62.
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Eosinophilic Lung Disease: Accompanied with 12 Cases. Sevim T, etal., Turk Thorac J. 2015 Oct;16(4):172-179. doi: 10.5152/ttd.2015.4614. Epub 2015 Oct 1.
12. Rat immunoglobulin E heavy chain locus. Steen ML, etal., J Mol Biol 1984 Jul 25;177(1):19-32.
13. Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis. Wu YC, etal., J Allergy Clin Immunol. 2014 Sep;134(3):604-12. doi: 10.1016/j.jaci.2014.07.010.
14. Clinical Analysis of 77 Patients with Allergic Bronchopulmonary Aspergillosis in Peking Union Medical College Hospital. Zhang M and Gao J, Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017 Jun 20;39(3):352-357. doi: 10.3881/j.issn.1000-503X.2017.03.009.
Additional References at PubMed
PMID:633088   PMID:2492284   PMID:6292865   PMID:6803238   PMID:6820340  


Genomics

Comparative Map Data
Ighe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06138,066,728 - 138,068,606 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06147,059,437 - 147,061,209 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera6129,872,683 - 129,874,561 (-)NCBICelera
RGSC_v3.16138,265,953 - 138,270,304 (-)NCBI
Cytogenetic Map6q32NCBI
IGHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,600,066 - 105,601,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,597,691 - 105,601,728 (-)Ensemblhg38GRCh38
GRCh3714106,066,403 - 106,068,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,137,324 - 105,139,109 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1486,119,850 - 86,126,707 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,254,966 - 86,262,620 (-)NCBIHuRef
CHM1_114106,062,729 - 106,064,390 (-)NCBICHM1_1
T2T-CHM13v2.01499,852,516 - 99,854,177 (-)NCBIT2T-CHM13v2.0
Ighe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,232,883 - 113,236,868 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,232,880 - 113,236,868 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812113,269,263 - 113,273,248 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,269,260 - 113,273,248 (-)Ensemblmm10GRCm38
MGSCv3712114,507,474 - 114,511,459 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera12114,451,920 - 114,461,277 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.1NCBI

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:65
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000006912
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D6Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86138,161,833 - 138,161,926 (+)Marker Load Pipeline
mRatBN7.26132,340,793 - 132,340,886 (+)MAPPERmRatBN7.2
Rnor_6.06138,066,182 - 138,066,274NCBIRnor6.0
Rnor_5.06147,058,788 - 147,058,880UniSTSRnor5.0
RGSC_v3.46138,261,562 - 138,261,655RGDRGSC3.4
RGSC_v3.46138,261,563 - 138,261,655UniSTSRGSC3.4
Celera6129,872,137 - 129,872,229UniSTS
RGSC_v3.16138,267,749 - 138,267,842RGD
RH 3.4 Map6784.2UniSTS
RH 3.4 Map6784.2RGD
RH 2.0 Map61126.9RGD
Cytogenetic Map6q32UniSTS
D6Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86138,161,499 - 138,161,632 (+)Marker Load Pipeline
mRatBN7.26132,340,459 - 132,340,592 (+)MAPPERmRatBN7.2
Rnor_6.06138,065,848 - 138,065,980NCBIRnor6.0
Rnor_5.06147,058,454 - 147,058,586UniSTSRnor5.0
RGSC_v3.46138,261,228 - 138,261,361RGDRGSC3.4
RGSC_v3.46138,261,229 - 138,261,361UniSTSRGSC3.4
Celera6129,871,803 - 129,871,935UniSTS
RGSC_v3.16138,267,415 - 138,267,548RGD
RH 3.4 Map6783.79UniSTS
RH 3.4 Map6783.79RGD
RH 2.0 Map61129.0RGD
Cytogenetic Map6q32UniSTS
D6Arb2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86138,161,477 - 138,161,746 (+)Marker Load Pipeline
mRatBN7.26132,340,437 - 132,340,706 (+)MAPPERmRatBN7.2
Rnor_6.06138,065,826 - 138,066,094NCBIRnor6.0
Rnor_5.06147,058,432 - 147,058,700UniSTSRnor5.0
RGSC_v3.46138,261,206 - 138,261,475RGDRGSC3.4
RGSC_v3.46138,261,207 - 138,261,475UniSTSRGSC3.4
Celera6129,871,781 - 129,872,049UniSTS
RGSC_v3.16138,267,393 - 138,267,662RGD
RH 3.4 Map6782.8UniSTS
RH 3.4 Map6782.8RGD
RH 2.0 Map61127.8RGD
SHRSP x BN Map682.8898RGD
Cytogenetic Map6q32UniSTS
D6Arb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,339,579 - 132,339,866 (+)MAPPERmRatBN7.2
Rnor_6.06138,064,968 - 138,065,254NCBIRnor6.0
Rnor_5.06147,057,574 - 147,057,860UniSTSRnor5.0
RGSC_v3.46138,260,348 - 138,260,635RGDRGSC3.4
RGSC_v3.46138,260,349 - 138,260,635UniSTSRGSC3.4
Celera6129,870,923 - 129,871,209UniSTS
RGSC_v3.16138,266,535 - 138,266,822RGD
RH 3.4 Map6783.0UniSTS
RH 3.4 Map6783.0RGD
RH 2.0 Map61125.3RGD
SHRSP x BN Map683.0399RGD
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression


Sequence


Protein Sequences
GenBank Protein AAA41364 (Get FASTA)   NCBI Sequence Viewer  
  BAB40315 (Get FASTA)   NCBI Sequence Viewer  
  CAA25439 (Get FASTA)   NCBI Sequence Viewer  
  P01855 (Get FASTA)   NCBI Sequence Viewer  
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01855-F1-model_v2 AlphaFold P01855 1-429 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2880 AgrOrtholog
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig/MHC_CS UniProtKB/Swiss-Prot
  Ig_C1-set UniProtKB/Swiss-Prot
  Immune_Resp_Modulators UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
NCBI Gene Ighe ENTREZGENE
PANTHER TAPASIN UniProtKB/Swiss-Prot
Pfam C1-set UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
PhenoGen Ighe PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  IG_MHC UniProtKB/Swiss-Prot
SMART IGc1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt IGHE_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-19 Ighe  immunoglobulin heavy constant epsilon  Ighe  immunoglobulin heavy chain (epsilon polypeptide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Ighe  immunoglobulin heavy chain (epsilon polypeptide)    Immunoglobulin heavy chain (epsilon polypeptide)  Name updated 625702 APPROVED
2002-06-10 Ighe  Immunoglobulin heavy chain (epsilon polypeptide)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript consists of two mRNA transcripts with one encoding the membrane binding form of the epsilon-chain 633089