Sh2b2 (SH2B adaptor protein 2) - Rat Genome Database

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Gene: Sh2b2 (SH2B adaptor protein 2) Heterocephalus glaber
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Symbol: Sh2b2
Name: SH2B adaptor protein 2
RGD ID: 18936305
Description: ENCODES a protein that exhibits SH2 domain binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); antigen receptor-mediated signaling pathway (ortholog); B cell receptor signaling pathway (ortholog); PARTICIPATES IN insulin signaling pathway; FOUND IN actin filament (ortholog); ruffle (ortholog); stress fiber (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH2B adapter protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474015,266,653 - 15,278,165 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474015,266,759 - 15,289,420 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Sh2b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474015,266,653 - 15,278,165 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474015,266,759 - 15,289,420 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
SH2B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387102,285,141 - 102,321,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7102,284,995 - 102,321,712 (+)Ensemblhg38GRCh38
GRCh377101,928,432 - 101,962,178 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367101,715,166 - 101,748,898 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347101,521,886 - 101,555,612NCBI
Celera796,937,415 - 96,974,023 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef796,518,618 - 96,555,244 (+)NCBIHuRef
CHM1_17101,856,547 - 101,892,227 (+)NCBICHM1_1
T2T-CHM13v2.07103,602,545 - 103,639,107 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27101,285,864 - 101,322,461 (+)NCBI
Sh2b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395136,247,003 - 136,275,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5136,247,001 - 136,275,410 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385136,218,147 - 136,246,595 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5136,218,147 - 136,246,556 (-)Ensemblmm10GRCm38
MGSCv375136,694,019 - 136,720,773 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365136,502,776 - 136,529,530 (-)NCBIMGSCv36mm8
Celera5133,234,728 - 133,261,476 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.93NCBI
Sh2b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,063,812 - 26,093,468 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1226,064,486 - 26,093,467 (+)EnsemblGRCr8
mRatBN7.21220,427,057 - 20,456,845 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,429,043 - 20,456,844 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1221,568,557 - 21,596,621 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,181,267 - 22,209,333 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,247,079 - 21,274,830 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,471,477 - 23,501,043 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,473,270 - 23,501,036 (+)Ensemblrn6Rnor6.0
Rnor_5.01225,472,225 - 25,501,387 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41221,544,434 - 21,572,232 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1222,198,080 - 22,225,866 (+)NCBICelera
RGSC_v3.11221,534,314 - 21,562,110 (+)NCBI
Cytogenetic Map12q12NCBI
Sh2b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545615,253,856 - 15,265,845 (-)Ensembl
ChiLan1.0NW_00495545615,253,711 - 15,265,874 (-)NCBIChiLan1.0ChiLan1.0
LOC100987922
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2688,678,181 - 88,703,893 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17137,006,683 - 137,034,320 (+)NCBINHGRI_mPanPan1
SH2B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,795,756 - 7,820,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,795,373 - 7,819,843 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha69,490,633 - 9,514,600 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.067,615,994 - 7,639,944 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,615,880 - 7,639,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,584,419 - 7,605,038 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,547,911 - 7,571,843 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,711,487 - 7,735,478 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sh2b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,215,641 - 132,236,929 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,799,568 - 1,822,028 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,799,610 - 1,820,889 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl39,670,815 - 9,695,629 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.139,670,838 - 9,695,325 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,455,164 - 9,467,362 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH2B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,862,922 - 10,900,967 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,864,188 - 10,883,437 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660705,502,499 - 5,541,690 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh2b2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11617,773,681 - 17,801,297 (+)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000021729   ⟹   ENSHGLP00000021520
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474015,266,653 - 15,278,165 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000021730   ⟹   ENSHGLP00000021521
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474015,266,923 - 15,278,165 (-)Ensembl
RefSeq Acc Id: XM_004840118   ⟹   XP_004840175
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474015,266,759 - 15,289,420 (-)NCBI
RefSeq Acc Id: XM_004840119   ⟹   XP_004840176
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474015,266,759 - 15,289,420 (-)NCBI
RefSeq Acc Id: XM_004840120   ⟹   XP_004840177
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474015,266,759 - 15,289,420 (-)NCBI
RefSeq Acc Id: XM_004840121   ⟹   XP_004840178
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474015,266,759 - 15,287,192 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004840175 (Get FASTA)   NCBI Sequence Viewer  
  XP_004840176 (Get FASTA)   NCBI Sequence Viewer  
  XP_004840177 (Get FASTA)   NCBI Sequence Viewer  
  XP_004840178 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021520
RefSeq Acc Id: XP_004840177   ⟸   XM_004840120
- Peptide Label: isoform X3
- UniProtKB: A0AAX6NZ16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004840176   ⟸   XM_004840119
- Peptide Label: isoform X2
- UniProtKB: A0AAX6NZ34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004840175   ⟸   XM_004840118
- Peptide Label: isoform X1
- UniProtKB: A0AAX6NZ96 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004840178   ⟸   XM_004840121
- Peptide Label: isoform X4
- UniProtKB: A0AAX6NZ23 (UniProtKB/TrEMBL),   G5AXB0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000021520   ⟸   ENSHGLT00000021729
Ensembl Acc Id: ENSHGLP00000021521   ⟸   ENSHGLT00000021730


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015375 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000021729 ENTREZGENE
Gene3D-CATH 6.10.140.110 UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
  SH2 domain UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Phe_ZIP UniProtKB/TrEMBL
  Phe_ZIP_sf UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH2B UniProtKB/TrEMBL
  SH2B2_SH2 UniProtKB/TrEMBL
KEGG Report hgl:101724022 UniProtKB/TrEMBL
NCBI Gene Sh2b2 ENTREZGENE
PANTHER SH2B ADAPTER PROTEIN UniProtKB/TrEMBL
  SH2B ADAPTER PROTEIN 2 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  Phe_ZIP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Phenylalanine zipper UniProtKB/TrEMBL
  SH2 domain UniProtKB/TrEMBL
UniProt A0AAX6NZ16 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6NZ23 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6NZ34 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6NZ96 ENTREZGENE, UniProtKB/TrEMBL
  G5AXB0 ENTREZGENE, UniProtKB/TrEMBL