Pdpr (pyruvate dehydrogenase phosphatase regulatory subunit) - Rat Genome Database

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Gene: Pdpr (pyruvate dehydrogenase phosphatase regulatory subunit) Heterocephalus glaber
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Symbol: Pdpr
Name: pyruvate dehydrogenase phosphatase regulatory subunit
RGD ID: 18934224
Description: INVOLVED IN positive regulation of pyruvate decarboxylation to acetyl-CoA (ortholog); ASSOCIATED WITH Joubert syndrome (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,423,917 - 12,492,966 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474612,426,081 - 12,492,966 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pdpr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,423,917 - 12,492,966 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474612,426,081 - 12,492,966 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
PDPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381670,113,626 - 70,163,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1670,114,246 - 70,162,537 (+)Ensemblhg38GRCh38
GRCh371670,147,529 - 70,196,440 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,705,030 - 68,752,685 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1655,305,783 - 55,318,599 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1656,000,281 - 56,034,180 (+)NCBIHuRef
CHM1_11671,555,144 - 71,602,818 (+)NCBICHM1_1
T2T-CHM13v2.01675,922,058 - 75,974,584 (+)NCBIT2T-CHM13v2.0
Pdpr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,821,232 - 111,866,402 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8111,821,262 - 111,863,706 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388111,094,609 - 111,139,781 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,094,630 - 111,137,074 (+)Ensemblmm10GRCm38
MGSCv378113,618,645 - 113,659,044 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368113,981,418 - 114,021,817 (+)NCBIMGSCv36mm8
Celera8115,325,916 - 115,359,375 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.95NCBI
Pdpr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,974,611 - 56,019,045 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1955,974,550 - 56,019,044 (+)EnsemblGRCr8
mRatBN7.21939,065,226 - 39,109,695 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,065,157 - 39,109,688 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1945,876,107 - 45,909,545 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,529,449 - 46,562,895 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,840,033 - 48,873,118 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1949,750,949 - 49,795,600 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1947,874,453 - 47,919,104 (+)NCBILyon_Normotensive
Lyon_Hypertensive1949,749,212 - 49,793,864 (+)NCBILyon_Hypertensive
F344_StmMcwi1947,511,831 - 47,545,183 (+)NCBIF344_StmMcwi
Rnor_6.01943,107,852 - 43,149,243 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,109,427 - 43,149,210 (-)Ensemblrn6Rnor6.0
Rnor_5.01953,933,343 - 53,973,781 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,025,633 - 41,058,989 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,462,557 - 38,495,915 (+)NCBICelera
RGSC_v3.11941,030,532 - 41,063,855 (+)NCBI
Cytogenetic Map19q12NCBI
Pdpr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554843,010,918 - 3,044,004 (-)Ensembl
ChiLan1.0NW_0049554843,007,435 - 3,044,060 (-)NCBIChiLan1.0ChiLan1.0
PDPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21884,017,672 - 84,067,296 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11689,953,418 - 90,002,934 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01654,868,840 - 54,919,077 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,210,472 - 76,239,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl576,213,566 - 76,239,852 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha576,166,902 - 76,196,312 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0576,646,289 - 76,682,979 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl576,646,292 - 76,682,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,468,772 - 76,505,252 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0576,280,014 - 76,316,315 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,772,087 - 76,808,437 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdpr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,215,965 - 36,257,021 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,332,093 - 23,373,340 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,332,093 - 23,373,151 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,187,427 - 13,227,033 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1613,187,377 - 13,230,601 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2613,272,323 - 13,289,911 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,296,772 - 53,341,206 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604716,082,058 - 16,128,130 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdpr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11730,792,143 - 30,835,849 (+)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000018118   ⟹   ENSHGLP00000017941
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474612,423,917 - 12,492,966 (-)Ensembl
RefSeq Acc Id: XM_004842857   ⟹   XP_004842914
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474612,426,081 - 12,492,965 (-)NCBI
RefSeq Acc Id: XM_004842858   ⟹   XP_004842915
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474612,426,081 - 12,492,966 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004842914 (Get FASTA)   NCBI Sequence Viewer  
  XP_004842915 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB04677 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000017941
GenBank Protein JAN97810 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004842915   ⟸   XM_004842858
- Peptide Label: isoform X2
- UniProtKB: G5B5W6 (UniProtKB/TrEMBL),   A0AAX6P3A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842914   ⟸   XM_004842857
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JU95 (UniProtKB/TrEMBL),   G5B5W6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000017941   ⟸   ENSHGLT00000018118


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012857 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000018118 ENTREZGENE
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
  Aminomethyltransferase beta-barrel domains UniProtKB/TrEMBL
  Aminomethyltransferase beta-barrel domains UniProtKB/TrEMBL
  D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/TrEMBL
  Probable tRNA modification gtpase trme, domain 1 UniProtKB/TrEMBL
InterPro FAD-dep_OxRdtase UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAO_M UniProtKB/TrEMBL
  GCV_T_C UniProtKB/TrEMBL
  GCV_T_N UniProtKB/TrEMBL
  GcvT/YgfZ_C UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/TrEMBL
  TrmE/GcvT_dom1 UniProtKB/TrEMBL
KEGG Report hgl:101715422 UniProtKB/TrEMBL
NCBI Gene Pdpr ENTREZGENE
PANTHER PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL UniProtKB/TrEMBL
  SARCOSINE DEHYDROGENASE-RELATED UniProtKB/TrEMBL
Pfam DAO UniProtKB/TrEMBL
  FAO_M UniProtKB/TrEMBL
  GCV_T UniProtKB/TrEMBL
  GCV_T_C UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/TrEMBL
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/TrEMBL
  Folate-binding domain UniProtKB/TrEMBL
  SSF101790 UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A0A0P6JU95 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6P3A0 ENTREZGENE, UniProtKB/TrEMBL
  G5B5W6 ENTREZGENE, UniProtKB/TrEMBL