Fam120c (family with sequence similarity 120 member C) - Rat Genome Database

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Gene: Fam120c (family with sequence similarity 120 member C) Rattus norvegicus
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Symbol: Fam120c
Name: family with sequence similarity 120 member C
RGD ID: 1564253
Description: Orthologous to human FAM120C (family with sequence similarity 120 member C); INTERACTS WITH bisphenol A; cobalt dichloride; glyphosate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: constitutive coactivator of PPAR-gamma-like protein 2; family with sequence similarity 120C; LOC317423; RGD1564253; similar to Protein CXorf17 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X23,765,089 - 23,922,059 (+)NCBIGRCr8
mRatBN7.2X20,324,046 - 20,477,831 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX20,323,381 - 20,477,275 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X20,481,800 - 21,016,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX20,484,517 - 21,015,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X22,433,417 - 22,502,893 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X21,229,220 - 21,287,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X40,666,514 - 40,823,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX20,580,430 - 20,732,823 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22658674   PMID:22681889  


Genomics

Comparative Map Data
Fam120c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X23,765,089 - 23,922,059 (+)NCBIGRCr8
mRatBN7.2X20,324,046 - 20,477,831 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX20,323,381 - 20,477,275 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X20,481,800 - 21,016,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX20,484,517 - 21,015,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X22,433,417 - 22,502,893 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X21,229,220 - 21,287,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X40,666,514 - 40,823,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX20,580,430 - 20,732,823 (+)NCBICelera
Cytogenetic MapXq12NCBI
FAM120C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X54,068,324 - 54,183,254 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX54,068,324 - 54,183,281 (-)EnsemblGRCh38hg38GRCh38
GRCh37X54,094,757 - 54,209,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X54,111,482 - 54,226,439 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,925,992 - 58,040,942 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX51,147,259 - 51,261,394 (-)NCBIHuRef
CHM1_1X54,085,791 - 54,200,408 (-)NCBICHM1_1
T2T-CHM13v2.0X53,358,212 - 53,473,143 (-)NCBIT2T-CHM13v2.0
Fam120c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,125,515 - 150,257,135 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,127,171 - 150,254,838 (+)EnsemblGRCm39 Ensembl
GRCm38X151,342,519 - 151,474,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX151,344,175 - 151,471,842 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X147,778,766 - 147,908,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X146,684,939 - 146,810,521 (+)NCBIMGSCv36mm8
CeleraX132,934,989 - 133,064,977 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Fam120c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554751,257,524 - 1,423,062 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554751,251,982 - 1,422,387 (-)NCBIChiLan1.0ChiLan1.0
FAM120C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X55,458,793 - 55,567,831 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X55,462,964 - 55,571,179 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X46,273,811 - 46,382,601 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X54,516,322 - 54,620,372 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX54,516,322 - 54,620,372 (-)Ensemblpanpan1.1panPan2
FAM120C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X45,780,015 - 45,943,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX45,571,840 - 46,081,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX37,240,467 - 37,403,794 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X46,107,948 - 46,271,561 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX46,107,975 - 46,324,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X45,599,451 - 45,762,935 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X46,050,004 - 46,213,484 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X46,117,070 - 46,280,612 (-)NCBIUU_Cfam_GSD_1.0
FAM120C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,777,923 - 46,904,579 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,777,904 - 46,904,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X52,507,081 - 52,554,605 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM120C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X50,178,851 - 50,305,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX50,183,496 - 50,305,691 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660864,141,097 - 4,257,549 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam120c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249091,668,635 - 1,858,574 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249091,668,720 - 1,858,483 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fam120c
882 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:669
Count of miRNA genes:302
Interacting mature miRNAs:407
Transcripts:ENSRNOT00000003565
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
RH128369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X20,335,480 - 20,335,686 (+)MAPPERmRatBN7.2
Rnor_6.0X20,495,467 - 20,495,672NCBIRnor6.0
Rnor_5.0X21,240,257 - 21,240,462UniSTSRnor5.0
RGSC_v3.4X40,677,505 - 40,677,710UniSTSRGSC3.4
CeleraX20,592,134 - 20,592,339UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 38 94 64 60 48 6 48 6 144 56 82 34 49 12

Sequence


Ensembl Acc Id: ENSRNOT00000093170   ⟹   ENSRNOP00000076254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX20,324,236 - 20,412,593 (+)Ensembl
Rnor_6.0 EnsemblX20,520,034 - 20,542,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093701   ⟹   ENSRNOP00000076162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX20,324,224 - 20,477,275 (+)Ensembl
Rnor_6.0 EnsemblX20,484,517 - 21,015,836 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110121   ⟹   ENSRNOP00000084900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX20,323,381 - 20,477,275 (+)Ensembl
RefSeq Acc Id: NM_001427708   ⟹   NP_001414637
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X23,767,565 - 23,920,857 (+)NCBI
RefSeq Acc Id: XM_039100523   ⟹   XP_038956451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X23,765,089 - 23,922,059 (+)NCBI
mRatBN7.2X20,324,046 - 20,477,831 (+)NCBI
RefSeq Acc Id: XM_063280060   ⟹   XP_063136130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X23,765,089 - 23,922,059 (+)NCBI
RefSeq Acc Id: XM_063280061   ⟹   XP_063136131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X23,765,089 - 23,828,481 (+)NCBI
RefSeq Acc Id: XM_063280062   ⟹   XP_063136132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X23,765,089 - 23,797,518 (+)NCBI
RefSeq Acc Id: XM_063280063   ⟹   XP_063136133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X23,765,089 - 23,917,319 (+)NCBI
Ensembl Acc Id: ENSRNOP00000076162   ⟸   ENSRNOT00000093701
Ensembl Acc Id: ENSRNOP00000076254   ⟸   ENSRNOT00000093170
RefSeq Acc Id: XP_038956451   ⟸   XM_039100523
- Peptide Label: isoform X2
- UniProtKB: A0A1W2Q678 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084900   ⟸   ENSRNOT00000110121
RefSeq Acc Id: XP_063136130   ⟸   XM_063280060
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136133   ⟸   XM_063280063
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063136131   ⟸   XM_063280061
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063136132   ⟸   XM_063280062
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001414637   ⟸   NM_001427708

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A1W2Q678-F1-model_v2 AlphaFold A0A1W2Q678 1-802 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564253 AgrOrtholog
BioCyc Gene G2FUF-2775 BioCyc
Ensembl Genes ENSRNOG00000062231 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093170.2 UniProtKB/TrEMBL
  ENSRNOT00000093701.2 UniProtKB/TrEMBL
  ENSRNOT00000110121.1 UniProtKB/TrEMBL
InterPro Coact_PPARg UniProtKB/TrEMBL
  PIN-like_dom_sf UniProtKB/TrEMBL
NCBI Gene 317423 ENTREZGENE
PANTHER PTHR15976 UniProtKB/TrEMBL
  PTHR15976:SF15 UniProtKB/TrEMBL
PhenoGen Fam120c PhenoGen
RatGTEx ENSRNOG00000062231 RatGTEx
Superfamily-SCOP SSF88723 UniProtKB/TrEMBL
UniProt A0A1W2Q678 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6F9_RAT UniProtKB/TrEMBL
  A0A8I6A052_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-06 Fam120c  family with sequence similarity 120 member C  FAM120C  family with sequence similarity 120C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 FAM120C  family with sequence similarity 120C  RGD1564253_predicted  similar to Protein CXorf17 homolog (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564253_predicted  similar to Protein CXorf17 homolog (predicted)  LOC317423  similar to Protein CXorf17 homolog  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317423  similar to Protein CXorf17 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL