Defb9 (defensin beta 9) - Rat Genome Database

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Gene: Defb9 (defensin beta 9) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Defb9
Name: defensin beta 9
RGD ID: 1563138
Description: Predicted to enable CCR6 chemokine receptor binding activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-9; beta-defensin 9; defensin, beta 9
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,883,161 - 76,886,073 (-)NCBIGRCr8
mRatBN7.21670,180,692 - 70,183,602 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,180,771 - 70,183,554 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,454,465 - 75,457,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,917,075 - 78,919,856 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,166,491 - 74,169,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,176,307 - 75,179,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,176,247 - 75,179,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,792,636 - 74,797,593 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,858,119 - 74,860,902 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,064,168 - 68,066,950 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16033865  


Genomics

Variants

.
Variants in Defb9
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:70
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000058061
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


Expression

RNA-SEQ Expression

ectoderm
mesenchyme
nervous system
renal system
reproductive system
4 35 4 35 5

Sequence


Ensembl Acc Id: ENSRNOT00000058061   ⟹   ENSRNOP00000054869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,180,771 - 70,183,554 (-)Ensembl
Rnor_6.0 Ensembl1675,176,247 - 75,179,089 (-)Ensembl
RefSeq Acc Id: NM_001037509   ⟹   NP_001032598
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,883,161 - 76,886,073 (-)NCBI
mRatBN7.21670,180,692 - 70,183,602 (-)NCBI
Rnor_6.01675,176,307 - 75,179,090 (-)NCBI
Rnor_5.01674,792,636 - 74,797,593 (-)NCBI
RGSC_v3.41674,858,119 - 74,860,902 (-)RGD
Celera1668,064,168 - 68,066,950 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51880 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054869
  ENSRNOP00000054869.3
  ENSRNOP00055011207
  ENSRNOP00060037082
  ENSRNOP00065010745
GenBank Protein Q32ZI2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032598   ⟸   NM_001037509
- Peptide Label: precursor
- UniProtKB: Q32ZI2 (UniProtKB/Swiss-Prot),   A0A0H2UHZ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054869   ⟸   ENSRNOT00000058061

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZI2-F1-model_v2 AlphaFold Q32ZI2 1-71 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563138 AgrOrtholog
BioCyc Gene G2FUF-10843 BioCyc
Ensembl Genes ENSRNOG00000038149 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055008270 UniProtKB/Swiss-Prot
  ENSRNOG00060025850 UniProtKB/Swiss-Prot
  ENSRNOG00065008979 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058061 UniProtKB/TrEMBL
  ENSRNOT00000058061.3 UniProtKB/Swiss-Prot
  ENSRNOT00055013981 UniProtKB/Swiss-Prot
  ENSRNOT00060044732 UniProtKB/Swiss-Prot
  ENSRNOT00065014349 UniProtKB/Swiss-Prot
InterPro Defensin_beta-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:641633 UniProtKB/Swiss-Prot
NCBI Gene 641633 ENTREZGENE
PANTHER BETA-DEFENSIN 10-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BETA-DEFENSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Defensin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Defb9 PhenoGen
RatGTEx ENSRNOG00000038149 RatGTEx
  ENSRNOG00055008270 RatGTEx
  ENSRNOG00060025850 RatGTEx
  ENSRNOG00065008979 RatGTEx
Superfamily-SCOP Defensin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHZ8 ENTREZGENE, UniProtKB/TrEMBL
  DEFB9_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-07 Defb9  defensin beta 9    beta-defensin 9  Name updated 1299863 APPROVED
2006-02-09 Defb9  beta-defensin 9      Symbol and Name status set to provisional 70820 PROVISIONAL