Defb37 (defensin beta 37) - Rat Genome Database

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Gene: Defb37 (defensin beta 37) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Defb37
Name: defensin beta 37
RGD ID: 1560790
Description: Predicted to enable CCR6 chemokine receptor binding activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and lung disease. Orthologous to human DEFB1 (defensin beta 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-defensin 37; beta-defensin 37-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,485,949 - 77,499,215 (+)NCBIGRCr8
mRatBN7.21670,783,532 - 70,796,798 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,783,554 - 70,796,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1676,060,482 - 76,073,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,523,215 - 79,536,290 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,772,631 - 74,785,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,083,173 - 75,094,963 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,083,172 - 75,095,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,676,330 - 74,687,465 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,597,785 - 75,618,379 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,642,072 - 68,654,354 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16033865  


Genomics

Variants

.
Variants in Defb37
68 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:103
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000058002
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
nervous system
renal system
reproductive system
respiratory system
8 11 13 11 11 30 8 19 30 2

Sequence


Ensembl Acc Id: ENSRNOT00000058002   ⟹   ENSRNOP00000054811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,783,554 - 70,796,892 (+)Ensembl
Rnor_6.0 Ensembl1675,083,172 - 75,095,108 (+)Ensembl
RefSeq Acc Id: NM_001411814   ⟹   NP_001398743
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,485,949 - 77,499,215 (+)NCBI
mRatBN7.21670,783,532 - 70,796,798 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001398743 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51903 (Get FASTA)   NCBI Sequence Viewer  
  EDM08963 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054811.2
Ensembl Acc Id: ENSRNOP00000054811   ⟸   ENSRNOT00000058002
RefSeq Acc Id: NP_001398743   ⟸   NM_001411814
- Peptide Label: precursor
- UniProtKB: F7FEH8 (UniProtKB/TrEMBL),   A6IWA9 (UniProtKB/TrEMBL),   Q32ZF9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FEH8-F1-model_v2 AlphaFold F7FEH8 1-63 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560790 AgrOrtholog
BioCyc Gene G2FUF-10811 BioCyc
Ensembl Genes ENSRNOG00000038115 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058002.4 UniProtKB/TrEMBL
InterPro Defensin_beta UniProtKB/TrEMBL
NCBI Gene 652921 ENTREZGENE
PANTHER BETA-DEFENSIN 37 UniProtKB/TrEMBL
  BETA-DEFENSIN-RELATED UniProtKB/TrEMBL
Pfam Defensin_beta UniProtKB/TrEMBL
PhenoGen Defb37 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038115 RatGTEx
Superfamily-SCOP Defensin-like UniProtKB/TrEMBL
UniProt A6IWA9 ENTREZGENE, UniProtKB/TrEMBL
  F7FEH8 ENTREZGENE, UniProtKB/TrEMBL
  Q32ZF9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Defb37  defensin beta 37  LOC100365497  beta-defensin 37-like  Data merged from RGD:2318983 1643240 APPROVED
2010-05-05 LOC100365497  beta-defensin 37-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-07 Defb37  defensin beta 37    beta-defensin 37  Name updated 1299863 APPROVED
2006-02-09 Defb37  beta-defensin 37      Symbol and Name status set to provisional 70820 PROVISIONAL