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Gene: Sh3bgrl1 (SH3 domain binding glutamate rich protein like 1) Rattus norvegicus

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Symbol:

Sh3bgrl1

Name:

SH3 domain binding glutamate rich protein like 1

RGD ID:

1560520

Description:

Predicted to enable protein-RNA adaptor activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of cytoplasmic translational initiation and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SH3BGRL (SH3 domain binding glutamate rich protein like); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC302363; MGC189398; RGD1560520; SH3 domain binding glutamate-rich protein like; SH3 domain binding glutamate-rich protein like 1; SH3 domain binding glutamic acid-rich protein like; SH3-binding domain glutamic acid-rich protein like; Sh3bgrl; similar to Sh3bgrl protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	78,242,704 - 78,343,633 (+)	NCBI		GRCr8
mRatBN7.2	X	74,167,029 - 74,263,783 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	74,166,871 - 74,263,783 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	75,680,414 - 75,779,166 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	79,153,820 - 79,252,347 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	76,719,333 - 76,820,270 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	80,213,209 - 80,312,393 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	80,213,332 - 80,309,936 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	80,392,505 - 80,491,085 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	97,453,828 - 97,559,778 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	75,437,192 - 75,534,605 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

autosomal hemophilia A (ISO)

factor VIII deficiency (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

alpha-Zearalanol (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlorpyrifos (EXP)

clofibrate (EXP)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dioxygen (EXP)

diuron (EXP)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

ethanol (ISO)

folic acid (ISO)

gentamycin (EXP)

indometacin (ISO)

ivermectin (ISO)

methidathion (ISO)

miconazole (ISO)

nefazodone (EXP)

nimesulide (EXP)

Nutlin-3 (ISO)

ozone (ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

potassium chromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rimonabant (ISO)

SB 431542 (ISO)

silicon dioxide (EXP,ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

trichloroethene (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of cytoplasmic translational initiation (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

cytoplasm (IBA)

cytosol (IEA,ISO)

plasma membrane (IEA)

Molecular Function

protein-RNA adaptor activity (ISO)

SH3 domain binding (IEA)

ubiquitin-like ligase-substrate adaptor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:19056867	PMID:20458337	PMID:23376485	PMID:23580065

Genomics

Comparative Map Data

Sh3bgrl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	78,242,704 - 78,343,633 (+)	NCBI		GRCr8
mRatBN7.2	X	74,167,029 - 74,263,783 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	74,166,871 - 74,263,783 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	75,680,414 - 75,779,166 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	79,153,820 - 79,252,347 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	76,719,333 - 76,820,270 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	80,213,209 - 80,312,393 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	80,213,332 - 80,309,936 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	80,392,505 - 80,491,085 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	97,453,828 - 97,559,778 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	75,437,192 - 75,534,605 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

SH3BGRL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	81,202,102 - 81,298,547 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	81,202,102 - 81,298,547 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	80,457,601 - 80,554,046 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	80,344,278 - 80,440,702 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	80,263,766 - 80,360,189	NCBI
Celera	X	80,697,460 - 80,794,205 (+)	NCBI		Celera
Cytogenetic Map	X	q21.1	NCBI
HuRef	X	74,037,981 - 74,133,875 (+)	NCBI		HuRef
CHM1_1	X	80,350,702 - 80,447,439 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	79,635,822 - 79,732,260 (+)	NCBI		T2T-CHM13v2.0

Sh3bgrl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	108,139,013 - 108,206,073 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	108,138,971 - 108,241,479 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	109,095,407 - 109,162,467 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	109,095,365 - 109,197,873 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	106,290,746 - 106,357,806 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	105,298,126 - 105,365,186 (+)	NCBI		MGSCv36	mm8
Celera	X	95,917,832 - 95,984,749 (+)	NCBI		Celera
Cytogenetic Map	X	D	NCBI
cM Map	X	47.92	NCBI

Sh3bgrl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955529	1,159,625 - 1,223,222 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955529	1,159,704 - 1,223,222 (+)	NCBI	ChiLan1.0	ChiLan1.0

SH3BGRL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	80,668,157 - 80,766,884 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	80,672,077 - 80,770,495 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	70,268,591 - 70,367,132 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	80,372,945 - 80,471,646 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	80,372,945 - 80,471,646 (+)	Ensembl	panpan1.1		panPan2

SH3BGRL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	62,467,789 - 62,601,678 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	62,467,107 - 62,599,820 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	53,213,241 - 53,351,399 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	63,775,155 - 63,913,539 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	63,774,408 - 63,915,580 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	61,437,020 - 61,575,191 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	63,074,508 - 63,213,069 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	62,641,163 - 62,779,323 (+)	NCBI		UU_Cfam_GSD_1.0

Sh3bgrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	56,341,545 - 56,416,926 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936547	2,661,575 - 2,739,418 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936547	2,661,747 - 2,737,338 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SH3BGRL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	X	64,617,350 - 64,709,006 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	74,216,694 - 74,244,825 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SH3BGRL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	70,201,334 - 70,303,432 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	70,200,824 - 70,304,503 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666067	10,840,774 - 10,969,170 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sh3bgrl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624852	7,033,344 - 7,113,021 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624852	7,033,344 - 7,113,039 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sh3bgrl1
266 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	831
Count of miRNA genes:	302
Interacting mature miRNAs:	383
Transcripts:	ENSRNOT00000042827
Prediction methods:	Microtar, Miranda, Pita, Pita,Microtar, Pita,Targetscan, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001173339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC169023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV766621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000042827 ⟹ ENSRNOP00000045257

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	80,213,332 - 80,309,936 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097939 ⟹ ENSRNOP00000089613

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	74,166,871 - 74,263,783 (+)	Ensembl

RefSeq Acc Id:

NM_001173339 ⟹ NP_001166810

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	78,242,704 - 78,343,633 (+)	NCBI
mRatBN7.2	X	74,167,141 - 74,263,781 (+)	NCBI
Rnor_6.0	X	80,213,209 - 80,312,393 (+)	NCBI
Rnor_5.0	X	80,392,505 - 80,491,085 (+)	NCBI
Celera	X	75,437,192 - 75,534,605 (+)	NCBI

Sequence:

show sequence

CCACCCTCCCGGTCCAACCTCTGTTTGGCCGGTAGCTCGGTAGCTCGGTTCCAGCCGTTGCTGC
AGCTGTTTCCCAGCCCTTTTCAAGACTCCGGTGACCGACCAGAAGCCCTTGTTTCCAGGATGGT
GATCCATGTATATATTGCATCTTCTTCTGGCTCTACGGCGATTAAGAAGAAACAGCAAGATGTG
CTTTGTTTCTTAGAAGCCAACAAAATAGGATTTGAAGAAAAAGATATTGCAGCTAATGAAGAGA
ATCGAAAGTGGATGAGAGAAAATGTACCTGAAGACAGTCGACCACCCACAGGGTACCCGTTGCC
ACCTCAGATTTTCAATGAAAGCCAGTACCGTGGGGATTATGATGCCTTCTTTGAAGCCCGAGAA
AATAATGCAGTTTATGCCTTTTTAGGCTTGACAGCACCACCTGGTTCAAAGGAAGCAGAAGCCC
AGGCAAAGCAGCAAGCATGAGTGTTCCATGTTCTTCCTTCAGCATCTTGAGAAATAATGAAATC
TCCATTGCTTTTAAAGAAATACCTGCTTCAAAAGAAATAGGCTTACATGTTGACATAATAGATT
AGTTGATGTTCTTGCATGCAAACAAGCATAATGAAAATGTGAACATGGTGGTAAGAAGTGAGAG
ATGAAGTTAAAACTTTAAGTAGGTAAAATAGAGTAGCATTGTTATCTGCAAAGGCATTTCATGT
TCTGTAAGGATTTCCCAAAAAACCTATGTGCTCCTTCTTTTATATTACTGTGTAGCTTAAGGAT
ATCTTCATTTAAATTTTGAGGAATTAAAGAGGAGAGAGAGAGGTGGGGGTAGGGAGAGAGAGGG
AGAGAGAAGGAGGGAGGGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACTTAAGACTCC
AAAAATGCCTCATTATCTTTAGTGAACATGAATATTTTGATGTAATGTTACTGTTGTTGAAATG
TATTTACAGGTTATGTTCATGATGTGTTAGCCATTGTAATTTCCTATGGTGACTGTGACATTCT
CCTTTTATAGGAGAAACGTGTATGCCCTGAACCACAAGTTTTCTAGGCTTCAAAATGTAACCTT
TCATTGCACTGTCAGTGATCAAAATAGTTGACTTCCTGCAAGACAAGAATTGACTGCATTCAAC
TGACAAATTTTCTTGCTTATACATGCAGTTATAATCATGTTTCTAAGTTGCTTGCCTCAGTAAA
ATGTGGATATATAAGGCATGGAGAAAAGATTGCAGTTCATTTTAAATTGGCCCTTCAATGCGAA
AGACACAGACTTTTAATTAACCATTATATTGCCCCTGATTGTTCAAGATATATTTTCTGTTGGT
GTTTGCTGAAAGTTGTAGTAGGAGCTCTCATCTCCTGCTTTACCACTGTTGCTGACCATGAACA
AAACCATTCCTAATAGGTAAGCCGTTAGTTTCAGTTTAGACAGACTGTGTCAACACATTGGTTC
AAGTAGAAAGAATCCCTAAGCAGACCTTGATCTTTTGAGAAAGTACATGTATCAAAGAAAAGGA
ACAATGTTTGAAACAGTTTGAAGATAAGCCTGACCCAAAGCATTCAACCAGAAGATGTTGATAT
TGTACCTTTGTCTCATACTTTAAAAACAAAACACTTTTTACTTCAAATTTTCTTTATCACTATA
TCTGCTATTTACTAAACTGTACTTGGCAAAAACATTCAACATACACTGAAGCCATATCTTTGTT
TACTGAAACTCAAACATAATTCTTAATGCTTTCAAAATAAATGTTCTTAAAAATTTTGTGTTAC
GGGGTTGGGGATTTAGCTCAGTGGTAGAGCGCTTGCCTAGCAAGCACAAGGCCCTGGGTTCGGT
CCCCAGCTCCGAAAAATAGAAAAGAAAAAAAAATTGTGTTACTCAACTTTAAATGTTAAACAGT
AATTTTGACGAATAATTGTTTATAGGTGTTTAGAAAGGAGAAAAACCATACTGAACGAAACAAA
ACAAAACAACAATAAAAAAACAATTTGAAGGCAATTTTTACTGACCTAAACTTTGAACTATGAA
TTGGAGTCAGAAGTACTGCATTTTTTCTTTTTCTTTTTACAAAAAGAAAACAGTTACTTGTGGA
GATCTCTATGGAAGACAGTACTTTAAATGAATTTTGGTGTGAACACAATACTTTTAGCCAATGC
TTTTCCTCAGCATTTCTAAATGAAACAGGTGATCCTTGCAATGTTCTATGTGGACAATATAACT
TTGGTTTTGTGTTAAATCATAGTGTCAGGATAGGCATTATTCAAAAATAGATGCATTGGAGAAT
GTTTATGTTGTCAGGATAAAACCCTGAAGTTTGTAGATTTAAAGTATACGTTTGAGTTGAATCG
TCTCCCATTGAAGCCTCTCATTTTGTTGATTGAGAAACATTCCTGATAGCTGAAAGAAAAGGAA
ATAAAAGTCTGAGAATTATGTTGAGTTTTTTTTAACTGCCACAGTATGTGCTTGAAGTAAAATT
CTTCCTGCTTTTCATAGTATCTTTGGCATATTTGTGTTTCTAAATCAGACCTGTTCATTTGTGA
GTTTCACATTTTAGAACTGATTTGCCTTTTAGAGATTTTGATCTTCAGAAAGAGTTCCATTTTC
AAACACACTATAAATTGTTAATTATATTGCTAAATGTGGACACTTTTTTGGGAACCTAAGCATA
GATGAATAGAGAATTTTGAAACAAAGATTGTTTTGATGGGGAAAGACTGAATAGAGAGTTTTGG
TGAAATCAGACTTTGCTTCTTAAGTAAAAACAACAAAAAAGTAGAACTCACATGGATTTTGTTA
AGCAGTTGTTGATGTTTAAAATATGCAAAGTACAACTTTAATTCTTTTCTATGGAACACCAATA
CTTCTTTTCATCTAATGAATTTCAATAAAACCAATTAAATGAAAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

Protein Sequences


Protein RefSeqs	NP_001166810	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI69023	(Get FASTA)	NCBI Sequence Viewer
	EDM07098	(Get FASTA)	NCBI Sequence Viewer
	EDM07099	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000089613.1

RefSeq Acc Id:	NP_001166810 ⟸ NM_001173339
- UniProtKB:	B5DFD8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVIHVYIASSSGSTAIKKKQQDVLCFLEANKIGFEEKDIAANEENRKWMRENVPEDSRPPTGYP LPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEAQAKQQA hide sequence

Ensembl Acc Id:

ENSRNOP00000045257 ⟸ ENSRNOT00000042827

Ensembl Acc Id:

ENSRNOP00000089613 ⟸ ENSRNOT00000097939

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DFD8-F1-model_v2	AlphaFold	B5DFD8	1-114	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560520	AgrOrtholog
BioCyc Gene	G2FUF-1875	BioCyc
Ensembl Genes	ENSRNOG00000002280	Ensembl
	ENSRNOG00000069303	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000097939.1	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Glut_rich_SH3_bd	UniProtKB/TrEMBL
	SH3BGR	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
KEGG Report	rno:302363	UniProtKB/TrEMBL
NCBI Gene	302363	ENTREZGENE
PANTHER	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN	UniProtKB/TrEMBL
	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN	UniProtKB/TrEMBL
Pfam	SH3BGR	UniProtKB/TrEMBL
PhenoGen	Sh3bgrl1	PhenoGen
PIRSF	SH3-bind_E-rich_L	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002280	RatGTEx
	ENSRNOG00000069303	RatGTEx
Superfamily-SCOP	Thiordxn-like_fd	UniProtKB/TrEMBL
UniProt	A0A8I6GHH3_RAT	UniProtKB/TrEMBL
	B5DFD8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-03-23	Sh3bgrl1	SH3 domain binding glutamate rich protein like 1	Sh3bgrl1	SH3 domain binding glutamate-rich protein like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2023-03-16	Sh3bgrl1	SH3 domain binding glutamate-rich protein like 1	Sh3bgrl	SH3 domain binding glutamate-rich protein like	Name and Symbol changed	629549	APPROVED
2014-03-13	Sh3bgrl	SH3 domain binding glutamate-rich protein like	Sh3bgrl	SH3 domain binding glutamic acid-rich protein like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-04	Sh3bgrl	SH3 domain binding glutamic acid-rich protein like	Sh3bgrl	SH3-binding domain glutamic acid-rich protein like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Sh3bgrl	SH3-binding domain glutamic acid-rich protein like	Sh3bgrl_predicted	SH3-binding domain glutamic acid-rich protein like (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Sh3bgrl_predicted	SH3-binding domain glutamic acid-rich protein like (predicted)	RGD1560520_predicted	similar to Sh3bgrl protein (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1560520_predicted	similar to Sh3bgrl protein (predicted)	LOC302363	similar to Sh3bgrl protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC302363	similar to Sh3bgrl protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar