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Gene: Ighg1 (immunoglobulin heavy constant gamma 1) Rattus norvegicus

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Symbol:

Ighg1

Name:

immunoglobulin heavy constant gamma 1

RGD ID:

1359539

Description:

Predicted to enable Fc-gamma receptor I complex binding activity and antigen binding activity. Predicted to be involved in B cell differentiation; adaptive immune response; and complement-dependent cytotoxicity. Predicted to act upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of immune response. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be part of IgG immunoglobulin complex and immunoglobulin complex, circulating. Predicted to be active in cytoplasm. Orthologous to human IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH 17beta-estradiol; benzo[a]pyrene; bisphenol A.

Type:

gene (Ensembl: protein-coding)

Previously known as:

Ighg; Immunoglobulin heavy chain (gamma polypeptide); LOC299354; RGD1359539; similar to IG GAMMA-1 CHAIN C REGION; similar to Ig gamma-1, chain C region

RGD Orthologs

Human

Mouse

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

NCBI Annotation Information:

Genome Annotation Status: not in current annotation release

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2 Ensembl	6	132,389,370 - 132,393,397 (-)	Ensembl				mRatBN7.2
Rnor_6.0	6	139,140,572 - 139,784,388 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	139,140,679 - 139,142,218 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	147,106,967 - 147,241,786 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	6	148,128,786 - 148,134,027 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	138,310,041 - 138,311,688 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	129,920,648 - 129,922,321 (-)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

myositis (ISO)

polycystic ovary syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

acetic acid (ISO)

acetohydrazide (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

benzene-1,2,4-triol (ISO)

benzethonium chloride (ISO)

benzo[a]pyrene (EXP)

biotin (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cadmium atom (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclophosphamide (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

Ganoderic acid C2 (ISO)

irinotecan (ISO)

lead(0) (ISO)

mercury dichloride (ISO)

Mesaconitine (EXP)

methyl methanesulfonate (ISO)

nitrofen (EXP)

phenobarbital (EXP)

senecionine (ISO)

silicon dioxide (ISO)

sodium fluoride (ISO)

tacrine (EXP)

tamibarotene (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

Trapidil (EXP)

troglitazone (ISO)

vinclozolin (EXP)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (ISO)

antibacterial humoral response (IBA,ISO)

antibody-dependent cellular cytotoxicity (ISO)

B cell differentiation (ISO)

complement activation, classical pathway (IBA,ISO)

complement-dependent cytotoxicity (ISO)

defense response to bacterium (ISO)

humoral immune response mediated by circulating immunoglobulin (ISO)

immunoglobulin mediated immune response (ISO)

phagocytosis, engulfment (ISO)

phagocytosis, recognition (ISO)

positive regulation of immune response (ISO)

positive regulation of phagocytosis (ISO)

positive regulation of type I hypersensitivity (ISO)

positive regulation of type IIa hypersensitivity (ISO)

Cellular Component

cytoplasm (ISO)

external side of plasma membrane (ISO)

extracellular space (ISO)

immunoglobulin complex, circulating (IBA,ISO)

Molecular Function

antigen binding (IBA,ISO)

Fc-gamma receptor I complex binding (ISO)

immunoglobulin receptor binding (IBA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-4 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:3016742	PMID:3149946	PMID:4098598	PMID:6952213	PMID:7688139	PMID:8041705	PMID:8047141	PMID:8418208	PMID:8552190	PMID:8566034	PMID:8769481	PMID:9492004
PMID:9551950	PMID:9707605	PMID:9743367	PMID:9834074	PMID:9834201	PMID:10395649	PMID:10704460	PMID:11057672	PMID:11714799	PMID:11901193	PMID:11911823	PMID:11911824
PMID:12477932	PMID:12867038	PMID:12882831	PMID:14988498	PMID:15692051	PMID:16275384	PMID:16492738	PMID:16502470	PMID:17658279	PMID:18762567	PMID:20031218	PMID:22516433
PMID:23376485	PMID:23533145	PMID:23580065	PMID:25645918

Genomics

Comparative Map Data

Ighg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2 Ensembl	6	132,389,370 - 132,393,397 (-)	Ensembl				mRatBN7.2
Rnor_6.0	6	139,140,572 - 139,784,388 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	139,140,679 - 139,142,218 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	147,106,967 - 147,241,786 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	6	148,128,786 - 148,134,027 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	138,310,041 - 138,311,688 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	129,920,648 - 129,922,321 (-)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

IGHG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	105,741,473 - 105,743,070 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	105,736,343 - 105,743,071 (-)	Ensembl			hg38	GRCh38
GRCh37	14	106,207,810 - 106,209,407 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	105,278,749 - 105,280,452 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	14	86,146,753 - 86,148,456 (-)	NCBI		Celera
Cytogenetic Map	14	q32.33	NCBI
HuRef	14	86,340,115 - 86,341,712 (-)	NCBI		HuRef
CHM1_1	14	106,106,771 - 106,107,520 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	100,012,671 - 100,014,268 (-)	NCBI		T2T-CHM13v2.0

Ighg1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	113,290,161 - 113,294,143 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	113,288,860 - 113,294,143 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	113,326,541 - 113,330,523 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	113,325,240 - 113,330,523 (-)	Ensembl			mm10	GRCm38
MGSCv37	12	114,564,755 - 114,568,734 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
Celera	12	114,512,547 - 114,780,893 (-)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI
cM Map	12	62.1	NCBI

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	50
Count of miRNA genes:	49
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000006975
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
6	6	21	28	24	12	6	12	6	41	21	9	2	11	12

Sequence

Nucleotide Sequences


GenBank Nucleotide	BC088271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC092584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC095846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M28670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006975 ⟹ ENSRNOP00000006975

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	132,389,370 - 132,393,397 (-)	Ensembl
Rnor_6.0 Ensembl	6	139,140,679 - 139,142,218 (-)	Ensembl

Protein Sequences


GenBank Protein	AAA60736	(Get FASTA)	NCBI Sequence Viewer
	AAH88271	(Get FASTA)	NCBI Sequence Viewer
	AAH92584	(Get FASTA)	NCBI Sequence Viewer
	AAH95846	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006975.5
GenBank Protein	P20759	(Get FASTA)	NCBI Sequence Viewer

Ensembl Acc Id:

ENSRNOP00000006975 ⟸ ENSRNOT00000006975

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P20759-F1-model_v2	AlphaFold	P20759	1-326	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359539	AgrOrtholog
Ensembl Genes	ENSRNOG00000030332	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006975.6	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7379698	IMAGE-MGC_LOAD
	IMAGE:7384581	IMAGE-MGC_LOAD
	IMAGE:7388075	IMAGE-MGC_LOAD
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_C1-set	UniProtKB/Swiss-Prot
	Immune_Resp_Modulators	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108947	IMAGE-MGC_LOAD
	MGC:109111	IMAGE-MGC_LOAD
	MGC:112743	IMAGE-MGC_LOAD
NCBI Gene	299354	ENTREZGENE
PANTHER	TAPASIN	UniProtKB/Swiss-Prot
Pfam	C1-set	UniProtKB/Swiss-Prot
PhenoGen	Ighg1	PhenoGen
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000030332	RatGTEx
SMART	IGc1	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
UniProt	IGHG1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-04-18	Ighg1	immunoglobulin heavy constant gamma 1	Ighg	Immunoglobulin heavy chain (gamma polypeptide)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-04-20	Ighg	Immunoglobulin heavy chain (gamma polypeptide)	Ighg	Immunoglobulin heavy chain (gamma polypeptide)	Type changed (type changed from [gene] to [protein-coding])	629549	APPROVED
2008-03-07	Ighg	Immunoglobulin heavy chain (gamma polypeptide)	RGD1359539	similar to Ig gamma-1, chain C region	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	RGD1359539	similar to Ig gamma-1, chain C region	LOC299354	similar to IG GAMMA-1 CHAIN C REGION	Symbol and Name updated	1299863	APPROVED
2005-07-29	LOC299354	similar to IG GAMMA-1 CHAIN C REGION			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)