Bag5 (BAG cochaperone 5) - Rat Genome Database

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Gene: Bag5 (BAG cochaperone 5) Rattus norvegicus
Analyze
Symbol: Bag5
Name: BAG cochaperone 5
RGD ID: 1310847
Description: Enables protein-folding chaperone binding activity and ubiquitin protein ligase binding activity. Involved in negative regulation of protein refolding; negative regulation of ubiquitin-protein transferase activity; and regulation of inclusion body assembly. Predicted to be located in inclusion body; mitochondrion; and perinuclear region of cytoplasm. Predicted to be part of junctional membrane complex. Predicted to be active in cytosol; membrane; and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2F. Orthologous to human BAG5 (BAG cochaperone 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BAG family molecular chaperone regulator 5; BAG-5; Bag5l1; bcl-2-associated athanogene 5; BCL2-associated athanogene 5; BCL2-associated athanogene 5-like 1; LOC366734; MGC95040
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,589,623 - 136,593,278 (-)NCBIGRCr8
mRatBN7.26130,768,467 - 130,772,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,768,141 - 130,772,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,935,653 - 130,939,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,232,623 - 131,236,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,598,651 - 130,602,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,180,640 - 136,185,651 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,182,006 - 136,185,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,276,057 - 136,279,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,231,088 - 144,234,743 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,491,438 - 136,495,093 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6128,323,687 - 128,328,063 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). Kalia LV, etal., PLoS One. 2011 Feb 16;6(2):e14695. doi: 10.1371/journal.pone.0014695.
4. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Kalia SK, etal., Neuron. 2004 Dec 16;44(6):931-45.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:19946888   PMID:21630459   PMID:23146300   PMID:24270810   PMID:24475098   PMID:24510904   PMID:25006867   PMID:26729625   PMID:30053369   PMID:31922242  


Genomics

Comparative Map Data
Bag5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,589,623 - 136,593,278 (-)NCBIGRCr8
mRatBN7.26130,768,467 - 130,772,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,768,141 - 130,772,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,935,653 - 130,939,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,232,623 - 131,236,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,598,651 - 130,602,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,180,640 - 136,185,651 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,182,006 - 136,185,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,276,057 - 136,279,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,231,088 - 144,234,743 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,491,438 - 136,495,093 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6128,323,687 - 128,328,063 (-)NCBICelera
Cytogenetic Map6q32NCBI
BAG5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814103,556,551 - 103,562,657 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14103,556,545 - 103,562,657 (-)EnsemblGRCh38hg38GRCh38
GRCh3714104,022,888 - 104,028,994 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,092,642 - 103,098,904 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414103,093,191 - 103,098,383NCBI
Celera1484,077,135 - 84,083,397 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1484,201,258 - 84,207,529 (-)NCBIHuRef
CHM1_114103,961,075 - 103,967,345 (-)NCBICHM1_1
T2T-CHM13v2.01497,792,597 - 97,798,702 (-)NCBIT2T-CHM13v2.0
Bag5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,675,922 - 111,679,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,675,922 - 111,679,691 (-)EnsemblGRCm39 Ensembl
GRCm3812111,709,488 - 111,713,256 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,709,488 - 111,713,257 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712112,947,699 - 112,951,467 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,157,666 - 112,161,064 (-)NCBIMGSCv36mm8
Celera12112,902,986 - 112,907,498 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.11NCBI
Bag5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555382,412,297 - 2,415,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555382,412,297 - 2,416,094 (-)NCBIChiLan1.0ChiLan1.0
BAG5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215104,716,445 - 104,722,120 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114103,932,405 - 103,938,620 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01484,182,879 - 84,189,180 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114103,994,248 - 103,998,958 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14103,997,524 - 103,998,927 (-)Ensemblpanpan1.1panPan2
BAG5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,318,730 - 71,324,743 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl871,321,625 - 71,322,992 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,829,710 - 70,835,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0871,594,260 - 71,600,623 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl871,594,262 - 71,600,622 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1871,283,335 - 71,289,698 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,323,119 - 71,329,275 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,722,298 - 71,728,659 (-)NCBIUU_Cfam_GSD_1.0
Bag5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,742,453 - 2,749,300 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366211,574,033 - 1,575,376 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366211,573,237 - 1,578,257 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAG5
(Sus scrofa - pig)
No map positions available.
BAG5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,496,664 - 81,502,969 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605368,800,966 - 68,807,186 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bag5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247341,315,052 - 1,320,627 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bag5
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:138
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000015333
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat

Markers in Region
BI282898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,768,960 - 130,769,151 (+)MAPPERmRatBN7.2
Rnor_6.06136,276,201 - 136,276,391NCBIRnor6.0
Rnor_6.06136,182,490 - 136,182,680NCBIRnor6.0
Rnor_5.06144,234,059 - 144,234,249UniSTSRnor5.0
RGSC_v3.46136,491,932 - 136,492,122UniSTSRGSC3.4
Celera6128,324,181 - 128,324,371UniSTS
RH 3.4 Map6780.91UniSTS
Cytogenetic Map6q32UniSTS
BE096446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,768,545 - 130,768,703 (+)MAPPERmRatBN7.2
Rnor_6.06136,275,786 - 136,275,943NCBIRnor6.0
Rnor_6.06136,182,075 - 136,182,232NCBIRnor6.0
Rnor_5.06144,234,507 - 144,234,664UniSTSRnor5.0
RGSC_v3.46136,491,517 - 136,491,674UniSTSRGSC3.4
Celera6128,323,766 - 128,323,923UniSTS
RH 3.4 Map6781.5UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19

Sequence


Ensembl Acc Id: ENSRNOT00000015333   ⟹   ENSRNOP00000015333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6136,276,057 - 136,279,399 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085594   ⟹   ENSRNOP00000071757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,768,141 - 130,772,970 (-)Ensembl
Rnor_6.0 Ensembl6136,182,006 - 136,185,651 (-)Ensembl
RefSeq Acc Id: NM_001008526   ⟹   NP_001008526
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,589,623 - 136,593,278 (-)NCBI
mRatBN7.26130,768,467 - 130,772,122 (-)NCBI
Rnor_6.06136,181,996 - 136,185,651 (-)NCBI
Rnor_5.06144,231,088 - 144,234,743 (+)NCBI
RGSC_v3.46136,491,438 - 136,495,093 (-)RGD
Celera6128,323,687 - 128,328,063 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240601   ⟹   XP_006240663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,589,973 - 136,592,724 (-)NCBI
mRatBN7.26130,768,467 - 130,771,920 (-)NCBI
Rnor_6.06136,180,640 - 136,185,353 (-)NCBI
Rnor_5.06144,231,088 - 144,234,743 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001008526   ⟸   NM_001008526
- UniProtKB: Q5QJC9 (UniProtKB/Swiss-Prot),   A6KBS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240663   ⟸   XM_006240601
- Peptide Label: isoform X1
- UniProtKB: Q5QJC9 (UniProtKB/Swiss-Prot),   A6KBS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071757   ⟸   ENSRNOT00000085594
Ensembl Acc Id: ENSRNOP00000015333   ⟸   ENSRNOT00000015333
Protein Domains
BAG

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QJC9-F1-model_v2 AlphaFold Q5QJC9 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694843
Promoter ID:EPDNEW_R5367
Type:initiation region
Name:Bag5l1_1
Description:BCL2-associated athanogene 5-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06136,185,690 - 136,185,750EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310847 AgrOrtholog
BioCyc Gene G2FUF-35829 BioCyc
Ensembl Genes ENSRNOG00000011527 Ensembl
  ENSRNOG00000058841 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055029976 UniProtKB/Swiss-Prot
  ENSRNOG00060028250 UniProtKB/Swiss-Prot
  ENSRNOG00065026030 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085594.2 UniProtKB/Swiss-Prot
  ENSRNOT00055051957 UniProtKB/Swiss-Prot
  ENSRNOT00060049085 UniProtKB/Swiss-Prot
  ENSRNOT00065044857 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123242 IMAGE-MGC_LOAD
InterPro BAG_chaperone_regulator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAG_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAG_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:366734 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95040 IMAGE-MGC_LOAD
NCBI Gene 366734 ENTREZGENE
PANTHER BAG FAMILY MOLECULAR CHAPERONE REGULATOR 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCL2-ASSOCIATED ATHANOGENE UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam BAG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bag5 PhenoGen
PROSITE BAG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011527 RatGTEx
  ENSRNOG00000058841 RatGTEx
  ENSRNOG00055029976 RatGTEx
  ENSRNOG00060028250 RatGTEx
  ENSRNOG00065026030 RatGTEx
SMART BAG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP BAG domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KBS7 ENTREZGENE, UniProtKB/TrEMBL
  BAG5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-06-01 Bag5  BAG cochaperone 5  Bag5l1  BCL2-associated athanogene 5-like 1  Data merged from RGD:9457021 737654 PROVISIONAL
2019-11-11 Bag5  BAG cochaperone 5  Bag5  BCL2-associated athanogene 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 Bag5l1  BCL2-associated athanogene 5-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Bag5  BCL2-associated athanogene 5  Bag5_predicted  BCL2-associated athanogene 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Bag5_predicted  BCL2-associated athanogene 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED