Arhgef40 (Rho guanine nucleotide exchange factor 40) - Rat Genome Database

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Gene: Arhgef40 (Rho guanine nucleotide exchange factor 40) Rattus norvegicus
Analyze
Symbol: Arhgef40
Name: Rho guanine nucleotide exchange factor 40
RGD ID: 1308093
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human ARHGEF40 (Rho guanine nucleotide exchange factor 40); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361034; RGD1308093; Rho guanine nucleotide exchange factor (GEF) 40; similar to FLJ00128 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,146,155 - 27,170,012 (+)NCBIGRCr8
mRatBN7.21524,672,645 - 24,696,510 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,672,763 - 24,696,510 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,443,819 - 27,467,885 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,399,586 - 28,423,331 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,652,519 - 26,676,264 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,377,916 - 28,403,090 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,377,996 - 28,403,090 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,189,787 - 32,214,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,412,068 - 27,433,673 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,381,978 - 27,448,481 (+)NCBI
Celera1524,980,711 - 25,001,821 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Arhgef40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,146,155 - 27,170,012 (+)NCBIGRCr8
mRatBN7.21524,672,645 - 24,696,510 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,672,763 - 24,696,510 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,443,819 - 27,467,885 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,399,586 - 28,423,331 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,652,519 - 26,676,264 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,377,916 - 28,403,090 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,377,996 - 28,403,090 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,189,787 - 32,214,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,412,068 - 27,433,673 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,381,978 - 27,448,481 (+)NCBI
Celera1524,980,711 - 25,001,821 (+)NCBICelera
Cytogenetic Map15p14NCBI
ARHGEF40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,061,264 - 21,090,248 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,070,273 - 21,090,248 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,538,463 - 21,558,407 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,608,367 - 20,627,876 (+)NCBINCBI36Build 36hg18NCBI36
Celera141,399,096 - 1,418,597 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,659,082 - 1,679,063 (+)NCBIHuRef
CHM1_11421,540,206 - 21,560,196 (+)NCBICHM1_1
T2T-CHM13v2.01415,258,708 - 15,287,664 (+)NCBIT2T-CHM13v2.0
Arhgef40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,222,158 - 52,243,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,222,176 - 52,243,708 (+)EnsemblGRCm39 Ensembl
GRCm381451,984,428 - 52,006,247 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,984,719 - 52,006,251 (+)EnsemblGRCm38mm10GRCm38
MGSCv371452,604,508 - 52,625,922 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,906,882 - 50,927,574 (+)NCBIMGSCv36mm8
Celera1448,965,121 - 48,986,199 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.75NCBI
Arhgef40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,837,899 - 1,856,005 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,837,903 - 1,854,490 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,521,434 - 22,540,742 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,737,357 - 21,757,229 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,884,772 - 1,904,120 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,967,448 - 19,986,844 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,969,664 - 19,985,466 (+)Ensemblpanpan1.1panPan2
ARHGEF40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,161,418 - 18,178,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,160,835 - 18,179,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,645,099 - 18,663,527 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,420,461 - 18,438,881 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,420,553 - 18,438,800 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,101,757 - 18,120,163 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,157,742 - 18,176,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,285,662 - 18,304,080 (+)NCBIUU_Cfam_GSD_1.0
Arhgef40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,365,417 - 32,384,116 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880274,488 - 292,742 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936880277,002 - 293,489 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,042,057 - 78,064,913 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,043,995 - 78,067,546 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARHGEF40
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,543,572 - 21,563,229 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,546,064 - 21,562,558 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,871,998 - 24,892,312 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef40
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,067,138 - 7,084,663 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,067,010 - 7,084,928 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef40
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:470
Count of miRNA genes:188
Interacting mature miRNAs:231
Transcripts:ENSRNOT00000015331, ENSRNOT00000028919
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
RH138212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,695,926 - 24,696,046 (+)MAPPERmRatBN7.2
Rnor_6.01528,402,507 - 28,402,626NCBIRnor6.0
Rnor_5.01532,213,739 - 32,213,858UniSTSRnor5.0
RGSC_v3.41527,434,234 - 27,434,353UniSTSRGSC3.4
Celera1525,001,238 - 25,001,357UniSTS
RH 3.4 Map15199.37UniSTS
Cytogenetic Map15p14UniSTS
MARC_7201-7202:996687628:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,693,432 - 24,693,838 (+)MAPPERmRatBN7.2
Rnor_6.01528,400,014 - 28,400,418NCBIRnor6.0
Rnor_5.01532,211,246 - 32,211,650UniSTSRnor5.0
RGSC_v3.41527,431,741 - 27,432,145UniSTSRGSC3.4
Celera1524,998,745 - 24,999,149UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001841260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005493755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000078475   ⟹   ENSRNOP00000071018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,672,763 - 24,696,510 (+)Ensembl
Rnor_6.0 Ensembl1528,377,996 - 28,403,090 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104210   ⟹   ENSRNOP00000082140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,675,361 - 24,696,510 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108540   ⟹   ENSRNOP00000096089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,672,763 - 24,696,510 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115526   ⟹   ENSRNOP00000079762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,672,763 - 24,694,781 (+)Ensembl
RefSeq Acc Id: NM_001271313   ⟹   NP_001258242
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,268 - 27,170,012 (+)NCBI
mRatBN7.21524,672,763 - 24,696,510 (+)NCBI
Rnor_6.01528,377,996 - 28,403,090 (+)NCBI
Rnor_5.01532,189,787 - 32,214,322 (+)NCBI
Celera1524,980,711 - 25,001,821 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093476   ⟹   XP_038949404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,158 - 27,168,868 (+)NCBI
mRatBN7.21524,672,647 - 24,695,366 (+)NCBI
RefSeq Acc Id: XM_039093477   ⟹   XP_038949405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,158 - 27,168,868 (+)NCBI
mRatBN7.21524,672,646 - 24,695,366 (+)NCBI
RefSeq Acc Id: XM_039093478   ⟹   XP_038949406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,157 - 27,169,507 (+)NCBI
mRatBN7.21524,672,646 - 24,695,971 (+)NCBI
RefSeq Acc Id: XM_039093479   ⟹   XP_038949407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,157 - 27,168,868 (+)NCBI
mRatBN7.21524,672,646 - 24,695,366 (+)NCBI
RefSeq Acc Id: XM_039093480   ⟹   XP_038949408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,155 - 27,164,239 (+)NCBI
mRatBN7.21524,672,646 - 24,690,735 (+)NCBI
RefSeq Acc Id: XM_063274400   ⟹   XP_063130470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,159 - 27,168,868 (+)NCBI
RefSeq Acc Id: XM_063274401   ⟹   XP_063130471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,159 - 27,169,507 (+)NCBI
RefSeq Acc Id: XM_063274402   ⟹   XP_063130472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,157 - 27,168,868 (+)NCBI
RefSeq Acc Id: XR_001841260
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,159 - 27,168,868 (+)NCBI
mRatBN7.21524,672,647 - 24,695,366 (+)NCBI
Rnor_6.01528,377,916 - 28,401,952 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005493755
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,156 - 27,168,868 (+)NCBI
mRatBN7.21524,672,646 - 24,695,366 (+)NCBI
RefSeq Acc Id: XR_010057835
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,156 - 27,168,868 (+)NCBI
RefSeq Acc Id: XR_010057836
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,156 - 27,168,868 (+)NCBI
RefSeq Acc Id: XR_010057837
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,160 - 27,168,868 (+)NCBI
RefSeq Acc Id: XR_010057838
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,146,160 - 27,168,868 (+)NCBI
RefSeq Acc Id: NP_001258242   ⟸   NM_001271313
- UniProtKB: A0A0G2JZE7 (UniProtKB/TrEMBL),   A0A8I5ZUE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071018   ⟸   ENSRNOT00000078475
RefSeq Acc Id: XP_038949406   ⟸   XM_039093478
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949405   ⟸   XM_039093477
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949407   ⟸   XM_039093479
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ARU3 (UniProtKB/TrEMBL),   A0A8I5ZRN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949408   ⟸   XM_039093480
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZRN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949404   ⟸   XM_039093476
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUE2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079762   ⟸   ENSRNOT00000115526
Ensembl Acc Id: ENSRNOP00000096089   ⟸   ENSRNOT00000108540
Ensembl Acc Id: ENSRNOP00000082140   ⟸   ENSRNOT00000104210
RefSeq Acc Id: XP_063130472   ⟸   XM_063274402
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ARU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130471   ⟸   XM_063274401
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JZE7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130470   ⟸   XM_063274400
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JZE7 (UniProtKB/TrEMBL)
Protein Domains
DH   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZE7-F1-model_v2 AlphaFold A0A0G2JZE7 1-1516 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699634
Promoter ID:EPDNEW_R10158
Type:initiation region
Name:Arhgef40_1
Description:Rho guanine nucleotide exchange factor 40
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,378,055 - 28,378,115EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308093 AgrOrtholog
BioCyc Gene G2FUF-13998 BioCyc
Ensembl Genes ENSRNOG00000052354 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078475.2 UniProtKB/TrEMBL
  ENSRNOT00000104210.1 UniProtKB/TrEMBL
  ENSRNOT00000108540.1 UniProtKB/TrEMBL
  ENSRNOT00000115526.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Rho_GEF_signaling-related UniProtKB/TrEMBL
KEGG Report rno:361034 UniProtKB/TrEMBL
NCBI Gene 361034 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 40 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PhenoGen Arhgef40 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052354 RatGTEx
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A0G2JZE7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRN9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARU3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-11 Arhgef40  Rho guanine nucleotide exchange factor 40  Arhgef40  Rho guanine nucleotide exchange factor (GEF) 40  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-26 Arhgef40  Rho guanine nucleotide exchange factor (GEF) 40  RGD1308093  similar to FLJ00128 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308093  similar to FLJ00128 protein   RGD1308093_predicted  similar to FLJ00128 protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308093_predicted  similar to FLJ00128 protein (predicted)  LOC361034_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361034_predicted  similar to FLJ00128 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL