Clba1 (clathrin binding box of aftiphilin containing 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Clba1 (clathrin binding box of aftiphilin containing 1) Rattus norvegicus
Analyze
Symbol: Clba1
Name: clathrin binding box of aftiphilin containing 1
RGD ID: 1307315
Description: Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be part of AP-1 adaptor complex. Predicted to be active in trans-Golgi network membrane. Orthologous to human CLBA1 (clathrin binding box of aftiphilin containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: clathrin binding box of aftiphilin containing; clathrin-binding box of aftiphilin-containing protein 1; hypothetical protein LOC362793; LOC362793; MGC105548; RGD1307315; uncharacterized protein C14orf79 homolog; uncharacterized protein CLBA1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,703,947 - 137,710,743 (+)NCBIGRCr8
mRatBN7.26131,882,866 - 131,889,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,882,609 - 131,889,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,052,761 - 132,059,557 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,342,975 - 132,349,889 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,717,251 - 131,724,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,386,694 - 137,393,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,386,422 - 137,393,506 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,389,788 - 146,396,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,809,373 - 137,816,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,815,559 - 137,822,355 (+)NCBI
Celera6129,422,066 - 129,428,862 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Clba1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,703,947 - 137,710,743 (+)NCBIGRCr8
mRatBN7.26131,882,866 - 131,889,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,882,609 - 131,889,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,052,761 - 132,059,557 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,342,975 - 132,349,889 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,717,251 - 131,724,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,386,694 - 137,393,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,386,422 - 137,393,506 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,389,788 - 146,396,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,809,373 - 137,816,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,815,559 - 137,822,355 (+)NCBI
Celera6129,422,066 - 129,428,862 (+)NCBICelera
Cytogenetic Map6q32NCBI
CLBA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,985,788 - 105,001,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,985,775 - 105,010,482 (+)EnsemblGRCh38hg38GRCh38
GRCh3714105,452,125 - 105,461,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,523,661 - 104,532,900 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414104,526,537 - 104,532,900NCBI
Celera1485,506,829 - 85,516,068 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,646,461 - 85,655,693 (+)NCBIHuRef
CHM1_114105,390,377 - 105,399,616 (+)NCBICHM1_1
T2T-CHM13v2.01499,230,266 - 99,245,748 (+)NCBIT2T-CHM13v2.0
Clba1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,772,595 - 112,779,865 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,772,557 - 112,779,872 (+)EnsemblGRCm39 Ensembl
GRCm3812112,808,975 - 112,816,245 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,808,937 - 112,816,252 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712114,047,186 - 114,054,456 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,256,783 - 113,264,053 (+)NCBIMGSCv36mm8
Celera12114,017,579 - 114,024,842 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Clba1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,333,957 - 3,341,256 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,325,052 - 3,340,534 (+)NCBIChiLan1.0ChiLan1.0
CLBA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,167,242 - 106,188,879 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,386,674 - 105,397,168 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,634,349 - 85,649,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,419,840 - 105,429,263 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,419,834 - 105,441,870 (+)Ensemblpanpan1.1panPan2
CLBA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,448,580 - 72,454,685 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,443,323 - 72,454,191 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,959,132 - 71,967,232 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,734,778 - 72,742,877 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,736,027 - 72,742,877 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,417,326 - 72,423,576 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,461,885 - 72,468,127 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,855,875 - 72,863,973 (+)NCBIUU_Cfam_GSD_1.0
Clba1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,636,052 - 1,643,623 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621464,507 - 472,642 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621464,993 - 472,608 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLBA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,256,197 - 131,260,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLBA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,905,148 - 82,918,368 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,905,218 - 82,916,861 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,337,315 - 70,350,265 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clba1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734394,627 - 401,296 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624734394,718 - 401,828 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clba1
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:58
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000018568
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat

Markers in Region
RH130051  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,889,444 - 131,889,627 (+)MAPPERmRatBN7.2
Rnor_6.06137,393,273 - 137,393,455NCBIRnor6.0
Rnor_5.06146,396,367 - 146,396,549UniSTSRnor5.0
RGSC_v3.46137,815,952 - 137,816,134UniSTSRGSC3.4
Celera6129,428,645 - 129,428,827UniSTS
RH 3.4 Map6782.4UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000018568   ⟹   ENSRNOP00000018568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,882,609 - 131,889,662 (+)Ensembl
Rnor_6.0 Ensembl6137,386,422 - 137,393,506 (+)Ensembl
RefSeq Acc Id: NM_001008377   ⟹   NP_001008378
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,703,947 - 137,710,743 (+)NCBI
mRatBN7.26131,882,866 - 131,889,662 (+)NCBI
Rnor_6.06137,386,694 - 137,393,490 (+)NCBI
Rnor_5.06146,389,788 - 146,396,584 (+)NCBI
RGSC_v3.46137,809,373 - 137,816,169 (+)RGD
Celera6129,422,066 - 129,428,862 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008378 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86564 (Get FASTA)   NCBI Sequence Viewer  
  EDL97416 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018568.3
  ENSRNOP00055044801
  ENSRNOP00065040253
GenBank Protein Q5RJN9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008378   ⟸   NM_001008377
- UniProtKB: Q5RJN9 (UniProtKB/Swiss-Prot),   A6KBW5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018568   ⟸   ENSRNOT00000018568
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJN9-F1-model_v2 AlphaFold Q5RJN9 1-321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694855
Promoter ID:EPDNEW_R5378
Type:multiple initiation site
Name:Clba1_1
Description:clathrin binding box of aftiphilin containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06137,386,388 - 137,386,448EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307315 AgrOrtholog
BioCyc Gene G2FUF-35774 BioCyc
Ensembl Genes ENSRNOG00000013690 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055031276 UniProtKB/Swiss-Prot
  ENSRNOG00065028480 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018568.6 UniProtKB/Swiss-Prot
  ENSRNOT00055054167 UniProtKB/Swiss-Prot
  ENSRNOT00065049081 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7305233 IMAGE-MGC_LOAD
InterPro Aftin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362793 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105548 IMAGE-MGC_LOAD
NCBI Gene 362793 ENTREZGENE
PANTHER AFTIPHILIN A-RELATED UniProtKB/TrEMBL
  CLATHRIN_BDG DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16156 UniProtKB/Swiss-Prot
Pfam Clathrin_bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clba1 PhenoGen
RatGTEx ENSRNOG00000013690 RatGTEx
  ENSRNOG00055031276 RatGTEx
  ENSRNOG00065028480 RatGTEx
UniProt A6KBW5 ENTREZGENE, UniProtKB/TrEMBL
  CLBA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-31 Clba1  clathrin binding box of aftiphilin containing 1  Clba1  clathrin binding box of aftiphilin containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-07-18 Clba1  clathrin binding box of aftiphilin containing  RGD1307315  LOC362793  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307315  LOC362793  RGD1307315_predicted  LOC362793 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307315_predicted  LOC362793 (predicted)  LOC362793_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362793_predicted  LOC362793 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL