Tmem231 (transmembrane protein 231) - Rat Genome Database

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Gene: Tmem231 (transmembrane protein 231) Rattus norvegicus
Analyze
Symbol: Tmem231
Name: transmembrane protein 231
RGD ID: 1306153
Description: Predicted to be involved in cilium assembly; regulation of protein localization; and smoothened signaling pathway. Predicted to act upstream of or within several processes, including embryonic digit morphogenesis; in utero embryonic development; and neuroepithelial cell differentiation. Predicted to be located in membrane. Predicted to be part of MKS complex. Predicted to be active in ciliary membrane and ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome 20 and Meckel syndrome. Orthologous to human TMEM231 (transmembrane protein 231); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC361410; RGD1306153; similar to predicted CDS, putative protein of bilaterial origin (4J193)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,792,329 - 56,813,515 (-)NCBIGRCr8
mRatBN7.21939,883,077 - 39,904,296 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,883,077 - 39,904,269 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1946,746,928 - 46,768,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01947,400,262 - 47,421,425 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,645,666 - 49,666,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01944,137,444 - 44,158,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1944,137,423 - 44,158,624 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,944,534 - 54,965,717 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,852,743 - 41,874,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11941,857,677 - 41,878,808 (-)NCBI
Celera1939,243,669 - 39,264,949 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
ciliary membrane  (IBA,IEA,ISO,ISS)
ciliary transition zone  (IBA,ISO,ISS)
membrane  (ISO)
MKS complex  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:22179047  


Genomics

Comparative Map Data
Tmem231
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,792,329 - 56,813,515 (-)NCBIGRCr8
mRatBN7.21939,883,077 - 39,904,296 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,883,077 - 39,904,269 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1946,746,928 - 46,768,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01947,400,262 - 47,421,425 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,645,666 - 49,666,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01944,137,444 - 44,158,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1944,137,423 - 44,158,624 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,944,534 - 54,965,717 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,852,743 - 41,874,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11941,857,677 - 41,878,808 (-)NCBI
Celera1939,243,669 - 39,264,949 (-)NCBICelera
Cytogenetic Map19q12NCBI
TMEM231
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381675,536,741 - 75,556,286 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1675,536,741 - 75,556,289 (-)EnsemblGRCh38hg38GRCh38
GRCh371675,570,639 - 75,590,184 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361674,129,516 - 74,147,671 (-)NCBINCBI36Build 36hg18NCBI36
Celera1659,866,319 - 59,884,472 (-)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1661,325,687 - 61,343,854 (-)NCBIHuRef
CHM1_11676,984,383 - 77,002,552 (-)NCBICHM1_1
T2T-CHM13v2.01681,584,994 - 81,604,533 (-)NCBIT2T-CHM13v2.0
Tmem231
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,638,639 - 112,660,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8112,638,643 - 112,660,513 (-)EnsemblGRCm39 Ensembl
GRCm388111,912,007 - 111,933,813 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,912,011 - 111,933,881 (-)EnsemblGRCm38mm10GRCm38
MGSCv378114,435,918 - 114,457,691 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368114,798,691 - 114,820,464 (-)NCBIMGSCv36mm8
Celera8116,140,711 - 116,162,498 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map858.15NCBI
Tmem231
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554842,011,000 - 2,027,763 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554842,011,000 - 2,027,763 (+)NCBIChiLan1.0ChiLan1.0
TMEM231
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21885,256,144 - 85,274,769 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11691,178,614 - 91,197,429 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01656,107,360 - 56,126,172 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11675,455,303 - 75,473,870 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1675,455,303 - 75,473,874 (-)Ensemblpanpan1.1panPan2
TMEM231
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1575,246,043 - 75,266,705 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl575,246,043 - 75,265,021 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha575,223,325 - 75,243,854 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0575,560,076 - 75,580,362 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl575,560,131 - 75,580,357 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1575,496,023 - 75,516,249 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0575,331,271 - 75,351,576 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0575,822,602 - 75,842,877 (+)NCBIUU_Cfam_GSD_1.0
Tmem231
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934935,356,456 - 35,373,390 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647524,215,659 - 24,232,947 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647524,215,817 - 24,232,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM231
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl612,140,687 - 12,164,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1612,140,317 - 12,163,894 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2611,981,581 - 12,005,456 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233314
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1561,023,700 - 61,043,183 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl561,025,388 - 61,042,792 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604715,015,729 - 15,033,954 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem231
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474611,411,107 - 11,427,943 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474611,411,050 - 11,427,945 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem231
141 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:99
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000031243
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000031243   ⟹   ENSRNOP00000029280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1944,137,423 - 44,158,621 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088297   ⟹   ENSRNOP00000070302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1939,883,077 - 39,904,269 (-)Ensembl
Rnor_6.0 Ensembl1944,137,444 - 44,158,624 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108248   ⟹   ENSRNOP00000096645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1939,883,102 - 39,904,263 (-)Ensembl
RefSeq Acc Id: NM_001271031   ⟹   NP_001257960
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,792,329 - 56,813,515 (-)NCBI
mRatBN7.21939,883,077 - 39,904,260 (-)NCBI
Rnor_6.01944,137,444 - 44,158,624 (-)NCBI
Rnor_5.01954,944,534 - 54,965,717 (-)NCBI
Celera1939,243,669 - 39,264,949 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257960 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89891 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070302.2
  ENSRNOP00000096645.1
GenBank Protein Q5FVM1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001257960   ⟸   NM_001271031
- UniProtKB: Q5FVM1 (UniProtKB/Swiss-Prot),   A0A8L2R283 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029280   ⟸   ENSRNOT00000031243
Ensembl Acc Id: ENSRNOP00000070302   ⟸   ENSRNOT00000088297
Ensembl Acc Id: ENSRNOP00000096645   ⟸   ENSRNOT00000108248

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVM1-F1-model_v2 AlphaFold Q5FVM1 1-315 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701155
Promoter ID:EPDNEW_R11679
Type:multiple initiation site
Name:Tmem231_1
Description:transmembrane protein 231
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01944,158,627 - 44,158,687EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306153 AgrOrtholog
BioCyc Gene G2FUF-5637 BioCyc
Ensembl Genes ENSRNOG00000021517 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088297.2 UniProtKB/TrEMBL
  ENSRNOT00000108248.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7375277 IMAGE-MGC_LOAD
InterPro TMEM231 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361410 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109076 IMAGE-MGC_LOAD
NCBI Gene 361410 ENTREZGENE
PANTHER PTHR14605 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 231 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TM231 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem231 PhenoGen
RatGTEx ENSRNOG00000021517 RatGTEx
UniProt A0A8I6AR31_RAT UniProtKB/TrEMBL
  A0A8L2R283 ENTREZGENE, UniProtKB/TrEMBL
  A6IZB6_RAT UniProtKB/TrEMBL
  Q5FVM1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-02-12 Tmem231  transmembrane protein 231  RGD1306153  similar to predicted CDS, putative protein of bilaterial origin (4J193)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306153  similar to predicted CDS, putative protein of bilaterial origin (4J193)  RGD1306153_predicted  similar to predicted CDS, putative protein of bilaterial origin (4J193) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306153_predicted  similar to predicted CDS, putative protein of bilaterial origin (4J193) (predicted)  LOC361410_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361410_predicted  similar to predicted CDS, putative protein of bilaterial origin (4J193) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL