Prp2 (proline rich protein 2) - Rat Genome Database

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Gene: Prp2 (proline rich protein 2) Rattus norvegicus
Analyze
Symbol: Prp2
Name: proline rich protein 2
RGD ID: 1305082
Description: Orthologous to human PRR4 (proline rich 4); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362450; RP15; salivary proline-rich protein
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84167,331,491 - 167,335,068 (+)NCBIGRCr8
mRatBN7.24165,600,085 - 165,603,662 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx4171,884,809 - 171,888,467 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04167,667,827 - 167,671,485 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04166,301,861 - 166,305,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04166,076,156 - 166,079,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4166,076,156 - 166,079,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04228,642,155 - 228,645,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44169,646,577 - 169,650,154 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14169,891,512 - 169,895,090 (+)NCBI
Celera4154,197,390 - 154,200,967 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular characterization of rat multigene family encoding proline-rich proteins. Lin HH and Ann DK, Genomics 1991 May;10(1):102-13.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Prp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84167,331,491 - 167,335,068 (+)NCBIGRCr8
mRatBN7.24165,600,085 - 165,603,662 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx4171,884,809 - 171,888,467 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04167,667,827 - 167,671,485 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04166,301,861 - 166,305,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04166,076,156 - 166,079,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4166,076,156 - 166,079,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04228,642,155 - 228,645,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44169,646,577 - 169,650,154 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14169,891,512 - 169,895,090 (+)NCBI
Celera4154,197,390 - 154,200,967 (+)NCBICelera
Cytogenetic Map4q42NCBI
Prp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396132,572,874 - 132,577,665 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6132,572,876 - 132,578,199 (+)EnsemblGRCm39 Ensembl
GRCm386132,595,911 - 132,600,702 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6132,595,913 - 132,601,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv376132,545,964 - 132,550,720 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366132,561,639 - 132,566,395 (+)NCBIMGSCv36mm8
Cytogenetic Map6G1NCBI
cM Map664.03NCBI

Variants

.
Variants in Prp2
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:73
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000007124
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
BI279337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24165,602,487 - 165,603,002 (+)MAPPERmRatBN7.2
mRatBN7.24165,675,076 - 165,675,584 (+)MAPPERmRatBN7.2
Rnor_6.04166,151,135 - 166,151,642NCBIRnor6.0
Rnor_6.04166,078,559 - 166,079,073NCBIRnor6.0
Rnor_5.04228,644,558 - 228,645,072UniSTSRnor5.0
RGSC_v3.44169,648,980 - 169,649,494UniSTSRGSC3.4
Celera4154,199,793 - 154,200,307UniSTS
RH 3.4 Map41015.3UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
4 2 2 1 4 1 5 4 4 16 1

Sequence


Ensembl Acc Id: ENSRNOT00000007124   ⟹   ENSRNOP00000007124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4166,076,156 - 166,079,733 (+)Ensembl
RefSeq Acc Id: NM_001013211   ⟹   NP_001013229
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84167,331,491 - 167,335,068 (+)NCBI
mRatBN7.24165,600,085 - 165,603,662 (+)NCBI
Rnor_6.04166,076,156 - 166,079,733 (+)NCBI
Rnor_5.04228,642,155 - 228,645,732 (+)NCBI
RGSC_v3.44169,646,577 - 169,650,154 (+)RGD
Celera4154,197,390 - 154,200,967 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013229 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42064 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013229   ⟸   NM_001013211
- Peptide Label: precursor
- Sequence:
Ensembl Acc Id: ENSRNOP00000007124   ⟸   ENSRNOT00000007124

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU40-F1-model_v2 AlphaFold E9PU40 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305082 AgrOrtholog
BioCyc Gene G2FUF-42711 BioCyc
Ensembl Genes ENSRNOG00000005379 Ensembl
InterPro Pro-rich UniProtKB/TrEMBL
  TMEM171 UniProtKB/TrEMBL
KEGG Report rno:362450 UniProtKB/TrEMBL
NCBI Gene 362450 ENTREZGENE
PANTHER TRANSMEMBRANE PROTEIN 171 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 171 UniProtKB/TrEMBL
Pfam TMEM171 UniProtKB/TrEMBL
PhenoGen Prp2 PhenoGen
RatGTEx ENSRNOG00000005379 RatGTEx
SMART Pro-rich UniProtKB/TrEMBL
UniProt A6I547_RAT UniProtKB/TrEMBL
  Q04154_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Prp2  proline rich protein 2   Prp2_predicted  proline rich protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Prp2_predicted  proline rich protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED