| 12336741 | PML | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); cellular response to interleukin-4 (ort holog); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN nuclear membrane (ortholog) | 30 | 37232337 | 37278434 | Dog | 226 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12401260 | PRAM1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits lipid binding (inferred); protein kinase binding (inferred); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN plasma membrane (inferred); protein-containing complex (inferred) | 20 | 53035389 | 53047126 | Dog | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12101235 | ARK2N | arkadia (RNF111) N-terminal like PKA signaling regulator 2N | ENCODES a protein that exhibits metal ion binding (inferred); transcription corepressor activity (inferred); transferase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); response to activity (ortholog); skeletal muscle fiber development (ortholog); FOUND IN chromatin (inferred); nucleus (inferred); PML body (inferred) | 7 | 44991197 | 45071723 | Dog | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 12059651 | CHEK2 | checkpoint kinase 2 | ENCODES a protein that exhibits kinase activity (ortholog); protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to bisphenol A (ortholog); cellular response to gamma radiation (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); bone osteosarcoma (ortholog); breast cancer (ortholog); FOUND IN chromosome, telomeric region (inferred); nucleoplasm (inferred); PML body (inferred) | 26 | 22052256 | 22145675 | Dog | 339 | description | gene, protein-coding, MODEL [RefSeq] |
| 12116810 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | 26 | 251369 | 324699 | Dog | 37 | description | gene, protein-coding, MODEL [RefSeq] |
| 12395946 | ELF4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN natural killer cell proliferati on (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of interleukin-1 beta production (ortholog); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (ortholog); PML body (ortholog) | X | 101220524 | 101268050 | Dog | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 12307020 | GCNA | germ cell nuclear acidic peptidase | ENCODES a protein that exhibits SUMO polymer binding (ortholog); INVOLVED IN protein-DNA covalent cross-linking repair (ortholog); ASSOCIATED WITH azoospermia (ortholog); spermatogenic failure 3 (ortholog); X-linked spermatogenic failure 4 (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (orthol og); PML body (ortholog) | X | 55859750 | 55881164 | Dog | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12060104 | HIPK3 | homeodomain interacting protein kinase 3 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN negative regulation of JUN kinase activity (ortholog); peptidyl-serine phosphorylation (ortholog); peptidyl-threonine phosphorylation (ortholog); FOUND IN PML weight:700;'>PML body (ortholog) | 18 | 34305208 | 34397593 | Dog | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 40909002 | KIAA1586 | KIAA1586 ortholog | ENCODES a protein that exhibits metal ion binding (inferred); SUMO ligase activity (inferred); transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription initiation by RNA polymerase II (inferred); negative regulation of tr ansforming growth factor beta receptor signaling pathway (inferred); ASSOCIATED WITH schizophrenia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Dog | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 12164803 | LOC491788 | small ubiquitin-related modifier 1-like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN PML body organization (ortholog); FOUND IN nucleus (inferred) | X | 21742066 | 21743108 | Dog | 12 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12083380 | LRCH4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (inferred); positive regulation of toll-like receptor signaling pathway (inferred); FOUND IN plasma membrane (inferred); PML body (inferred) | 6 | 9088815 | 9113629 | Dog | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 12187130 | RNF6 | ring finger protein 6 | ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN negative regulation of axon extension (ortholog); positive regulation of DNA-templated transcription (ortholog); protein K48-linked ubiquitination (ortholog); ASSOCIATED WITH Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); hepatocellular carcinoma (ortholog); FOUND IN axon (ortholog); PML body (ortholog) | 25 | 13199201 | 13240347 | Dog | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 12317477 | RPAIN | RPA interacting protein | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN protein import into nucleus (ortholog); response to UV (ortholog); FOUND IN cytoplasm (ortholog); PML body (ortholog) | 5 | 31359735 | 31366108 | Dog | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 12423766 | SERBP1 | SERPINE1 mRNA binding protein 1 | ENCODES a protein that exhibits ribosome binding (ortholog); SUMO binding (ortholog); translation elongation factor binding (ortholog); INVOLVED IN negative regulation of translation (ortholog); PML body organization (ortholog); regulation of apoptotic process ( ortholog); ASSOCIATED WITH Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | 5 | 43170553 | 43187281 | Dog | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 12123626 | SIMC1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); SUMO polymer binding (inferred); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); PML body (inferred) | 4 | 36980710 | 37058032 | Dog | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12425642 | SKIL | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); PML body (ortholog) | 34 | 34871770 | 34898681 | Dog | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 12425200 | TDG | thymine DNA glycosylase | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); nucleic acid binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of embryonic development (ortholog); ASSOCIAT ED WITH Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN PML body (ortholog) | 15 | 42493593 | 42516868 | Dog | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 12081128 | TRIM16 | tripartite motif containing 16 | ENCODES a protein that exhibits DNA binding (inferred); interleukin-1 binding (inferred); metal ion binding (inferred); INVOLVED IN positive regulation of DNA-templated transcription (inferred); positive regulation of interleukin-1 beta production (inferred); positive regulation of keratinocyte diff erentiation (inferred); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); PML body (inferred) | 5 | 39146505 | 39167857 | Dog | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 12324307 | ZCCHC12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); nucleus (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A | X | 91004777 | 91008019 | Dog | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 12419552 | ZMYM2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin conjugating enzyme binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FO UND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | 25 | 18040081 | 18158241 | Dog | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 12173554 | ZNF451 | zinc finger protein 451 | ENCODES a protein that exhibits metal ion binding (inferred); SUMO ligase activity (inferred); transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription initiation by RNA polymerase II (inferred); negative regulation of tr ansforming growth factor beta receptor signaling pathway (inferred); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | 12 | 24260862 | 24350890 | Dog | 22 | description | gene, protein-coding, MODEL [RefSeq] |