| 12416215 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein tyrosine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to epidermal growth factor sti mulus (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | 9 | 22760373 | 22785367 | Dog | 335 | symbol , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 40910703 | TOB1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (inferred); SMAD binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); regulation of SMAD p rotein signal transduction (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred) | 9 | 26736805 | 26741119 | Dog | 32 | name | gene, protein-coding, MODEL [RefSeq] |
| 12081408 | TOB2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (inferred); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog) | 10 | 23817778 | 23830330 | Dog | 15 | name | gene, protein-coding, MODEL [RefSeq] |
| 12220588 | ERBIN | erbb2 interacting protein | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic specialization (ortholog) | 2 | 51613344 | 51730868 | Dog | 41 | name | gene, protein-coding, MODEL [RefSeq] |
| 12310144 | BTC | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB4-ERBB4 signaling path way (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | 15 | 64133051 | 64159155 | Dog | 43 | description | gene, protein-coding, MODEL [RefSeq] |
| 12329637 | CPNE3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (inferred); calcium-dependent protein binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to calcium ion (inferred); cellular response to growth factor stimulus (inferred); ERBB2 ;'>ERBB2 signaling pathway (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (inferred); cytoplasm (inferred); cytosol (inferred) | 29 | 32682019 | 32736871 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12168776 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog) | 32 | 30073541 | 30166904 | Dog | 156 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12141175 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH bisphenol A | 13 | 62857325 | 62877831 | Dog | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 12428789 | MAP2K2 | mitogen-activated protein kinase kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); MAP-kinase scaffold activity (ortholog); INVOLVED IN epithelial cell proliferation involved in lung morphogenesis (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); breast cancer (ortholog); cardiofaciocutaneous syndrome (ortholog); FOUND IN cell cortex (ortholog); cell-cell junction (ortholog); cytoplasmic side of plasma membrane (ortholog) | 20 | 55465460 | 55487629 | Dog | 133 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12362760 | NRG2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | 2 | 35085192 | 35264509 | Dog | 36 | description | gene, protein-coding, MODEL [RefSeq] |