This gene encodes a member of the urotensin family of peptide hormones. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone before secretion into the plasma. Mice lacking the encoded protein have a significantly decreased low density lipoprotein choles
terol profile and hepatic steatosis that is consistent with decreased hepatocyte de novo cholesterol synthesis and apolipoprotein B secretion. [provided by RefSeq, Sep 2016]
Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in regulation of blood pressure. Predicted to be located in extracellular region. Is expressed in brain; male reproductive gland or organ; and metanephros. Orthologous to human UTS2
Predicted to enable urotensin II receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; regulation of blood pressure; and regulation of circadian sleep/wake cycle. Predicted to be located in early endosome and recycling endosome. Predicted to be a