| 1318062 | Rp1 | retinitis pigmentosa 1 (human) | This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of ou ter segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jun 2019] | 1 | 4185896 | 4479508 | Mouse | 130 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1552899 | Cd180 | CD180 antigen | Acts upstream of or within B cell proliferation involved in immune response; cellular response to lipopolysaccharide; and positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in mitotic spindle; nuclear lumen; and plasma membrane. Predicted to be active in ex tracellular matrix and extracellular space. Orthologous to human CD180 (CD180 molecule). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 102830055 | 102843139 | Mouse | 107 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735593 | Cyp4a10 | cytochrome P450, family 4, subfamily a, polypeptide 10 | Predicted to enable monooxygenase activity. Predicted to be involved in several processes, including fatty acid metabolic process; icosanoid metabolic process; and positive regulation of icosanoid secretion. Located in intracellular membrane-bounded organelle. Is expressed in liver and urinary syste m. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 115375484 | 115390846 | Mouse | 226 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733083 | Gpr83 | G protein-coupled receptor 83 | Enables neuropeptide receptor activity. Involved in feeding behavior; neuropeptide signaling pathway; and phospholipase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within response to glucocorticoid. Located in non-motile cilium and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and pectoralis. Orthologous to human GPR83 (G protein-coupled receptor 83). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 14771038 | 14782085 | Mouse | 87 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1620631 | Mapre2 | microtubule-associated protein, RP/EB family, member 2 | Enables microtubule plus-end binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of ARF protein signal transduction; positive regulation of focal adhesion disassembly; and positive regulation of keratinocyte migration. Located in focal a dhesion. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE2 (microtubule associated protein RP/EB family member 2). [provided by Alliance of Genome Resources, Apr 2025] | 18 | 23885390 | 24026918 | Mouse | 119 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1617245 | Rp1l1 | retinitis pigmentosa 1 homolog like 1 | This gene encodes a member of the doublecortin family. This protein is a retinal-specific protein. It contains two N-terminal doublecortin domains, which can assemble and stabilize axonemal microtubules, but lacks the C-terminal repetitive regions including the 16aa repeat found in human RP1 ='font-weight:700;'>RP1L1. This protein and the RP1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. [provided by RefSeq, Sep 2010] | 14 | 64229880 | 64270955 | Mouse | 63 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1615143 | Stk19 | serine/threonine kinase 19 | Predicted to enable double-stranded DNA binding activity and protein homodimerization activity. Predicted to be involved in positive regulation of Ras protein signal transduction and positive regulation of single strand break repair. Predicted to be located in cytoplasm and nuclear speck. Orthologou s to human WHR1 (winged helix repair factor 1). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 35042969 | 35055879 | Mouse | 83 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1623307 | Klrb1c | killer cell lectin-like receptor subfamily B member 1C | Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Is expressed in thymus primordium. Orthologous to h uman KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 128755448 | 128765514 | Mouse | 32 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732486 | Pnliprp1 | pancreatic lipase related protein 1 | Predicted to enable calcium ion binding activity; lipoprotein lipase activity; and phospholipase A1 activity. Predicted to be involved in several processes, including cholesterol homeostasis; high-density lipoprotein particle remodeling; and triglyceride catabolic process. Predicted to be located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Orthologous to human PNLIPRP1 (pancreatic lipase related protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 58717319 | 58732601 | Mouse | 103 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320184 | Smg5 | SMG5 nonsense mediated mRNA decay factor | Predicted to enable enzyme binding activity; telomerase RNA binding activity; and telomeric DNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of dephosphorylation; and regulation of telomere maintenance. Predicted to be located in cytoplasm and nucleus. Predicted to be part of telomerase holoenzyme complex. Orthologous to human SMG5 (SMG5 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 88242050 | 88269645 | Mouse | 93 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1621559 | Vti1b | vesicle transport through interaction with t-SNAREs 1B | Predicted to enable SNAP receptor activity; SNARE binding activity; and chloride channel inhibitor activity. Predicted to be involved in several processes, including Golgi vesicle transport; regulation of protein localization to plasma membrane; and retrograde transport, endosome to Golgi. Located i n Golgi apparatus; membrane; and perinuclear region of cytoplasm. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human VTI1B (vesicle transport through interaction with t-SNAREs 1B). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 79202791 | 79219428 | Mouse | 139 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 15038115 | Hprt-ps1 | hypoxanthine guanine phosphoribosyl transferase pseudogene 1 | | | | | Mouse | | old_gene_symbol | gene, pseudo |
| 1322521 | Map3k4 | mitogen-activated protein kinase kinase kinase 4 | Enables protein kinase activity. Involved in intracellular signal transduction and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and placenta development. Located in cy toplasm. Is expressed in several structures, including central nervous system; future brain; and genitourinary system. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 12446508 | 12537683 | Mouse | 191 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1552306 | Prpf31 | pre-mRNA processing factor 31 | Predicted to enable several functions, including U4atac snRNA binding activity; identical protein binding activity; and snRNP binding activity. Predicted to be involved in ribonucleoprotein complex localization and spliceosomal tri-snRNP complex assembly. Predicted to be located in Cajal body and nu clear speck. Predicted to be part of nucleus. Is expressed in several structures, including hemolymphoid system; liver; lung; muscle tissue; and retina. Used to study retinitis pigmentosa 11. Human ortholog(s) of this gene implicated in retinitis pigmentosa 11. Orthologous to human PRPF31 (pre-mRNA processing factor 31). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 3632984 | 3645484 | Mouse | 157 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332454 | Khdrbs2 | KH domain containing, RNA binding, signal transduction associated 2 | The protein encoded by this gene is similar to the src associated in mitosis, 68 kDa protein, which is an RNA-binding protein and a substrate for Src-family tyrosine kinases during mitosis. This protein has a KH RNA-binding motif and proline-rich motifs which may be SH2 and SH3 domain binding sites. A similar rat protein is an RNA-binding protein which is tyrosine phosphorylated by Src during mitosis. These studies also suggest that the rat protein may function as an adaptor protein for Src by binding the SH2 and SH3 domains of various other proteins. [provided by RefSeq, Jul 2008] | 1 | 32211683 | 32744305 | Mouse | 82 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1551609 | Kazald1 | Kazal-type serine peptidase inhibitor domain 1 | Predicted to enable insulin-like growth factor binding activity. Acts upstream of or within extracellular matrix organization. Located in interstitial matrix. Is expressed in several structures, including bone; cap mesenchyme; jaw; nose; and testis. Orthologous to human KAZALD1 (Kazal type serine pe ptidase inhibitor domain 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 45063404 | 45067728 | Mouse | 89 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |