Predicted to enable several functions, including guanyl ribonucleotide binding activity; retromer complex binding activity; and small GTPase binding activity. Involved in lipophagy; neurotransmitter receptor transport, postsynaptic endosome to lysosome; and vesicle-mediated transport in synapse. Act
s upstream of or within with a positive effect on establishment of vesicle localization. Located in several cellular components, including late endosome membrane; lipid droplet; and phagophore assembly site membrane. Is active in glutamatergic synapse and lysosome. Colocalizes with lysosomal membrane. Is expressed in several structures, including 1-cell stage embryo; cerebral cortex; lung mesenchyme; oocyte; and primitive endoderm. Used to study Charcot-Marie-Tooth disease type 2B. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Predicted to be involved in mitophagy. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including adipose tissue; ganglia; gut; hemolymphoid system; and male reproductive gland or organ. Orthologous to human RIMOC1 (RAB7A i