protein phosphatase 2, regulatory subunit A, alpha
Enables protein serine/threonine phosphatase activity. Involved in T cell homeostasis and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positi
ve regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol. Part of protein phosphatase type 2A complex. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Jul 2025]
PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1
Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in mitotic G2/M transition checkpoint; positive regulation of cell growth; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm
and nuclear body. Is expressed in embryo. Orthologous to human PABIR1 (PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1). [provided by Alliance of Genome Resources, Apr 2025]