Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts ups
tream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Jul 2025]
17
28451715
28520446
Mouse
677
symbol , old_gene_name , PhenoGen , description , old_gene_symbol