Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; lipid binding activity; and nuclear receptor activity. Involved in several processes, including negative regulation of appetite; peroxisome proliferator activated receptor signaling pathway; and regulation of gen
e expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of biosynthetic process; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; early conceptus; gut; hemolymphoid system gland; and skeletal muscle. Used to study diabetes mellitus and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2025]
INVOLVED IN miRNA-mediated post-transcriptional gene silencing (inferred); ASSOCIATED WITH lung cancer (ortholog); Lung Neoplasms (ortholog); FOUND IN RISC complex (inferred); INTERACTS WITH (1->4)-beta-D-glucan; 6-propyl-2-thiouracil; diiodine