Pik3ca Gene Search Result

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1 records found for search term Pik3ca

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1551142	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Enables 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to hydrostatic pressure; and phosphatidyli ... (more) nositol 3-kinase/protein kinase B signal transduction. Acts upstream of with a negative effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to glucose stimulus; negative regulation of apoptotic process; and regulation of macromolecule metabolic process. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]	3	32451203	32520256	Mouse	719	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]