Enables Notch binding activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of endothelial cell differentiation. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; positive regulation of angiogenesis; and p
ositive regulation of aorta morphogenesis. Located in cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; early conceptus; genitourinary system; and gut. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Enables Notch binding activity. Involved in vasculogenesis. Acts upstream of or within negative regulation of smooth muscle cell migration. Located in extracellular space. Is expressed in several structures, including cardiovascular system; early conceptus; embryo mesenchyme; genitourinary system; a