| 732272 | Mapk8 | mitogen-activated protein kinase 8 | Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including generation of neurons; integrin-mediated signaling pathway; and positive regulation of protein metabolic process. Acts upstream of or within several processes, including cellul ar response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is active in Schaffer collateral - CA1 synapse and cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 33099855 | 33169213 | Mouse | 1738 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1318961 | Jkamp | JNK1/MAPK8-associated membrane protein | Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in endoplasmic reticulum membrane. Is expressed in brain; frontal bone; parietal bone; spinal cord; and trigeminal ganglion. Orthologous to human JKAMP (JNK1/MAPK8 font-weight:700;'>MAPK8 associated membrane protein). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 72132348 | 72148301 | Mouse | 72 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557450 | Jkampl | JNK1/MAPK8 associated membrane protein like | INVOLVED IN response to unfolded protein (inferred); FOUND IN membrane (inferred); INTERACTS WITH acrylamide (ortholog); bisphenol A (ortholog); fenvalerate (ortholog) | 6 | 73445563 | 73446621 | Mouse | 6 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1552682 | Mapk8ip1 | mitogen-activated protein kinase 8 interacting protein 1 | Enables kinesin binding activity and protein kinase binding activity. Involved in positive regulation of JNK cascade and regulation of CD8-positive, alpha-beta T cell proliferation. Acts upstream of or within several processes, including JUN phosphorylation; negative regulation of intrinsic apoptoti c signaling pathway; and regulation of DNA-templated transcription. Located in several cellular components, including dendrite; dentate gyrus mossy fiber; and neuronal cell body. Is expressed in several structures, including early conceptus; genitourinary system; musculature; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 92214021 | 92231608 | Mouse | 187 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1320223 | Mapk8ip2 | mitogen-activated protein kinase 8 interacting protein 2 | Enables kinesin binding activity. Involved in several processes, including behavioral fear response; excitatory postsynaptic potential; and regulation of neurotransmitter receptor activity. Acts upstream of or within JNK cascade. Located in cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2025] | 15 | 89338114 | 89346650 | Mouse | 124 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1558435 | Mapk8ip3 | mitogen-activated protein kinase 8 interacting protein 3 | Enables MAP-kinase scaffold activity; kinesin binding activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of neuron migration; and regulation of MAPK cascade. Acts upstream of or within several processes, i ncluding JNK cascade; lung development; and nervous system development. Located in several cellular components, including Golgi membrane; axolemma; and smooth endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; pancreas; retina; and spleen. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 25116480 | 25155951 | Mouse | 235 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1322668 | Spag9 | sperm associated antigen 9 | Enables several functions, including JUN kinase binding activity; MAP-kinase scaffold activity; and kinesin binding activity. Acts upstream of or within positive regulation of MAPK cascade; positive regulation of neuron differentiation; and striated muscle cell differentiation. Located in cytoplasm. Is expressed in central nervous system; dorsal root ganglion; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to human SPAG9 (sperm associated antigen 9). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 93886794 | 94016919 | Mouse | 186 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |