Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in several processes, including interleukin-1-mediated signaling pathway; negative regulation of cholesterol efflux; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, inc
luding cell surface receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; and response to peptidoglycan. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
interleukin-1 receptor-associated kinase 1 binding protein 1
Enables signaling adaptor activity. Involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human IRAK1