Enables orexin receptor activity. Involved in locomotion. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genito
urinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in
the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]