| 1617323 | Cchcr1 | coiled-coil alpha-helical rod protein 1 | Predicted to enable identical protein binding activity. Acts upstream of or within protein export from nucleus. Located in cytoplasm. Is expressed in brain ventricular layer; inferior colliculus; and pancreas epithelium. Used to study alopecia areata. Orthologous to human CCHCR 700;'>HCR1 (coiled-coil alpha-helical rod protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 35827914 | 35841912 | Mouse | 90 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737179 | Eif2ak1 | eukaryotic translation initiation factor 2 alpha kinase 1 | Enables heme binding activity; protein homodimerization activity; and protein kinase activity. Involved in negative regulation of cell population proliferation; negative regulation of hemoglobin biosynthetic process; and protein autophosphorylation. Acts upstream of or within several processes, incl uding macrophage differentiation; multicellular organismal-level iron ion homeostasis; and regulation of protein metabolic process. Located in cytoplasm. Is expressed in alimentary system; central nervous system; liver; nervous system; and spinal cord. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 143803586 | 143839535 | Mouse | 157 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 731041 | Hcrt | hypocretin | This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcr ight:700;'>Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015] | 11 | 100652519 | 100653757 | Mouse | 210 | symbol , PhenoGen , description | gene, protein-coding, REVIEWED [RefSeq] |
| 737545 | Hcrtr1 | hypocretin (orexin) receptor 1 | Predicted to enable orexin receptor activity and peptide hormone binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and li ver and biliary system. Orthologous to human HCRTR1 (hypocretin receptor 1). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 130024010 | 130033389 | Mouse | 108 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1553616 | Hcrtr2 | hypocretin (orexin) receptor 2 | Enables orexin receptor activity. Involved in locomotion. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genito urinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 76133162 | 76230905 | Mouse | 103 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |