Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity and RNA polymerase II CTD heptapeptide repeat P6 isomerase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including ali
Enables protein folding chaperone. Acts upstream of or within several processes, including nervous system development; positive regulation of BMP signaling pathway; and protein folding. Located in endoplasmic reticulum membrane and mitochondrial envelope. Is expressed in several structures, includin
g central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Used to study clubfoot and spina bifida. Orthologous to human FKBP8 (FKBP prolyl isomerase 8). [provided by Alliance of Genome Resources, Jul 2025]
This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splic