Fgd1 Gene Search Result

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4 records found for search term Fgd1

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1558012	Fgd1	FYVE, RhoGEF and PH domain containing 1	This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division ... (more) cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]	X	149829141	149872682	Mouse	112	symbol , old_gene_name , PhenoGen	gene, protein-coding, REVIEWED [RefSeq]
1320400	Fgd2	FYVE, RhoGEF and PH domain containing 2	Enables guanyl-nucleotide exchange factor activity and phosphatidylinositol phosphate binding activity. Acts upstream of or within positive regulation of JUN kinase activity. Located in early endosome; nucleus; and ruffle. Orthologous to human FGD2 (FYVE, RhoGEF and PH domain containing 2). [provide ... (more) d by Alliance of Genome Resources, Jul 2025]	17	29579878	29598509	Mouse	91	old_gene_name	gene, protein-coding, VALIDATED [RefSeq]
1323333	Fgd3	FYVE, RhoGEF and PH domain containing 3	Predicted to enable guanyl-nucleotide exchange factor activity. Involved in filopodium assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; cranial ganglion; dorsal root ganglion; lung; and spleen. Orthologous to ... (more) human FGD3 (FYVE, RhoGEF and PH domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]	13	49415030	49473783	Mouse	92	old_gene_name	gene, protein-coding, VALIDATED [RefSeq]
1332050	Fgd4	FYVE, RhoGEF and PH domain containing 4	This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal ner ... (more) ve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]	16	16234774	16418400	Mouse	173	old_gene_name	gene, protein-coding, REVIEWED [RefSeq]