Ezh2 Gene Search Result

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3 records found for search term Ezh2

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1312684	Ezh2	enhancer of zeste 2 polycomb repressive complex 2 subunit	Enables several functions, including DNA binding activity; RNA binding activity; and transcription corepressor activity. Involved in B cell differentiation; facultative heterochromatin formation; and regulation of circadian rhythm. Acts upstream of or within several processes, including cardiac musc ... (more) le hypertrophy in response to stress; negative regulation of cell differentiation; and regulation of DNA-templated transcription. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Jul 2025]	6	47507208	47613843	Mouse	599	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1619223	Suz12	SUZ12 polycomb repressive complex 2 subunit	This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2 ... (more) style='font-weight:700;'>EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]	11	79883932	79924949	Mouse	233	description	gene, protein-coding, REVIEWED [RefSeq]
1312814	Ezh1	enhancer of zeste 1 polycomb repressive complex 2 subunit	This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (Ezh2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 an ... (more) d results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]	11	101081941	101117268	Mouse	173	description	gene, protein-coding, REVIEWED [RefSeq]