This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Es
trogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Predicted to enable enzyme-substrate adaptor activity; mRNA binding activity; and single-stranded RNA binding activity. Involved in cytidine to uridine editing. Acts upstream of or within embryo implantation; mRNA localization resulting in post-transcriptional regulation of gene expression; and mRNA
modification. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; liver; and sensory organ. Human ortholog(s) of this gene implicated in gout. Orthologous to human A1CF (APOBEC1 complementation factor). [provided by Alliance of Genome Resources, Jul 2025]
Predicted to enable several functions, including NADPH-hemoprotein reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor. Predicted to be involved in electron transport chain. Predicted to be located in cytopla
sm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be active in cytosol. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1). [provided by Alliance of Genome Resources, Apr 2025]