| 732834 | Eif4e | eukaryotic translation initiation factor 4E | This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this prot ein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] | 3 | 138231952 | 138265457 | Mouse | 374 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 15037840 | Eif4e-ps | eukaryotic translation initiation factor 4E, pseudogene | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1550810 | Eif4e2 | eukaryotic translation initiation factor 4E member 2 | Predicted to enable RNA cap binding activity; translation initiation factor activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in P-body. Predicted to be part of eukaryotic translation initiation factor 4F compl ex. Is expressed in several structures, including brain; early conceptus; intestine; lung; and oocyte. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 87141633 | 87168210 | Mouse | 132 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1620031 | Eif4e3 | eukaryotic translation initiation factor 4E member 3 | Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in blood vessel; central nervous system; and sens ory organ. Orthologous to human EIF4E3 (eukaryotic translation initiation factor 4E family member 3). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 99599008 | 99669834 | Mouse | 112 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1558336 | Ngdn | neuroguidin, EIF4E binding protein | Predicted to be involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of protein localization to plasma membrane; and regulation of translation at postsynapse. Predicted to be located in mitochondrion an d nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in several cellular components, including glutamatergic synapse; nucleolus; and perforant pathway to dendrate granule cell synapse. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and cerebral cortex ventricular layer. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 55252911 | 55261595 | Mouse | 94 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1320333 | Eif4enif1 | eukaryotic translation initiation factor 4E nuclear import factor 1 | Enables mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of translation; and stem cell population maintenance. Located in P-body; cytosol; and nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; epithelium; metanephros; and ovary. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 3152344 | 3194588 | Mouse | 117 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 733442 | Eif4ebp1 | eukaryotic translation initiation factor 4E binding protein 1 | Enables eukaryotic initiation factor 4E binding activity. Involved in IRES-dependent translational initiation of linear mRNA. Acts upstream of or within cellular response to dexamethasone stimulus; insulin receptor signaling pathway; and negative regulation of translational initiation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including central nervous system; oocyte; pancreas tip epithelium; skeletal musculature; and thymus. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 27750355 | 27765684 | Mouse | 525 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1321949 | Eif4ebp2 | eukaryotic translation initiation factor 4E binding protein 2 | Enables eukaryotic initiation factor 4E binding activity and translation repressor activity. Involved in several processes, including memory; negative regulation of translational initiation; and social behavior. Acts upstream of or within TOR signaling and insulin receptor signaling pathway. Predict ed to be located in nucleus. Predicted to be active in neuronal ribonucleoprotein granule and postsynapse. Is expressed in heart; liver; and lung. Used to study autism spectrum disorder. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 61268276 | 61288448 | Mouse | 146 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1622163 | Eif4ebp3 | eukaryotic translation initiation factor 4E binding protein 3 | Predicted to enable eukaryotic initiation factor 4E binding activity. Predicted to be involved in negative regulation of translational initiation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in gut; male reproductive gland or organ; and metanephros. Ortholog ous to human EIF4EBP3 (eukaryotic translation initiation factor 4E binding protein 3). [provided by Alliance of Genome Resources, Apr 2025] | 18 | 36797113 | 36799377 | Mouse | 71 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614948 | Eif4e1b | eukaryotic translation initiation factor 4E family member 1B | Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in early co nceptus and reproductive system. Orthologous to human EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 54931807 | 54936272 | Mouse | 35 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 15039202 | Eif4ebp1-ps1 | eukaryotic translation initiation factor 4E binding protein 1, pseudogene 1 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15039104 | Eif4ebp1-ps2 | eukaryotic translation initiation factor 4E binding protein 1, pseudogene 2 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1642920 | Maskbp3 | multiple ankyrin repeats single KH domain binding protein 3 | This locus represents naturally occurring read-through transcription between the neighboring Ankhd1 and Eif4ebp3 genes. Similar read-through transcription has also been observed in human, as defined by GeneID 404734. While there is partial transcript support for read-through transcription in mouse, there is currently insufficient support to determine the full-length nature of a mouse read-through transcript. [provided by RefSeq, May 2013] | | | | Mouse | | old_gene_name , description , old_gene_symbol | gene, protein-coding |
| 1313239 | Eif4g2 | eukaryotic translation initiation factor 4, gamma 2 | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-termin al region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 7 | 110667192 | 110682237 | Mouse | 173 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1550408 | Eif4g1 | eukaryotic translation initiation factor 4, gamma 1 | This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms t he eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015] | 16 | 20491457 | 20511633 | Mouse | 274 | description | gene, protein-coding, VALIDATED [RefSeq] |