Cldn16 Gene Search Result

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1 records found for search term Cldn16

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
733040	Cldn16	claudin 16	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel ... (more) l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is critical for renal paracellular epithelial transport of Ca(2+) and Mg(2+) in the thick ascending loop of Henle. The gene deficiency leads to specific alterations in renal Ca(2+) and Mg(2+) balance and also to disturbances in Na(+) handling. The interaction of this gene and the Cldn 19 gene is required for their assembly into tight junctions and for renal Mg(2+) reabsorption. This gene and the Cldn1 gene are clustered on chromosome 16. [provided by RefSeq, Aug 2010]	16	26281885	26301515	Mouse	92	symbol , PhenoGen	gene, protein-coding, REVIEWED [RefSeq]