The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The hum
an ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]
Enables protein kinase activator activity. Acts upstream of or within positive regulation of MAPK cascade. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous syste
m; heart; pancreas; and retina. Human ortholog(s) of this gene implicated in syndactyly-telecanthus-anogenital and renal malformations syndrome. Orthologous to human CCNQ (cyclin Q). [provided by Alliance of Genome Resources, Jul 2025]