| 10257 | C4b | complement C4B (Chido blood group) | Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Acts upstream of or within complement activation and immunoglobulin mediated immune response. Located in extracellular space. Is expressed in several structures, including hemolymphoid system; li ver; reproductive system; retina; and yolk sac. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to several human genes including C4A (complement C4A (Chido/Rodgers blood group)) and C4B (complement C4B (Chido/Rodgers blood group)). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 34947249 | 34962876 | Mouse | 209 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615407 | C4a | complement C4A (Rodgers blood group) | Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Acts upstream of or within complement activation. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficie ncy (multiple); and renal cell carcinoma. Orthologous to human C4A (complement C4A (Chido/Rodgers blood group)) and C4B (complement C4B (Chido/Rodgers blood group)). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 35028069 | 35042436 | Mouse | 134 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732956 | Cr1l | complement C3b/C4b receptor 1 like | Predicted to enable complement receptor activity and opsonin binding activity. Acts upstream of or within several processes, including cellular response to hypoxia; complement activation; and negative regulation of complement activation. Located in basolateral plasma membrane and external side of pl asma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in malaria. Orthologous to several human genes including CR1L (complement C3b/C4b receptor 1 like). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 194781019 | 194813878 | Mouse | 131 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 10258 | C4bp | complement component 4 binding protein | Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space and plasma membran e. Is expressed in foregut-midgut junction; midgut; midgut loop; renal calyx; and renal pelvis. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 130562510 | 130589365 | Mouse | 70 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732319 | Cfi | complement component factor i | This gene encodes a serine protease that plays an important role in the classical and alternative complement pathways where it cleaves C4b and C3b components of C3 and C5 convertases. The encoded preproprotein undergoes proteolytic processing to generate an acti ve, disulfide-linked heterodimeric enzyme comprised of heavy and light chains. [provided by RefSeq, Jul 2016] | 3 | 129630432 | 129668978 | Mouse | 222 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 10259 | C4bp-ps1 | complement component 4 binding protein, pseudogene 1 | PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH arsenous acid; bis(2-ethylhexyl) phthalate; bisphenol F | 1 | 130597939 | 130609308 | Mouse | 7 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 1314030 | Agpat3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | Enables lysophosphatidic acid acyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Ortholo gous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 78105008 | 78188335 | Mouse | 169 | UniProt , old_protein_id , UniProt Secondary | gene, protein-coding, VALIDATED [RefSeq] |
| 1553528 | Masp2 | MBL associated serine protease 2 | Predicted to enable several functions, including calcium-dependent protein binding activity; complement component C4b binding activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway. Predicted to be loc ated in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain and liver. Orthologous to human MASP2 (MBL associated serine protease 2). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 148679079 | 148699939 | Mouse | 142 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1550604 | Zp3r | zona pellucida 3 receptor | Involved in binding activity of sperm to zona pellucida. Acts upstream of or within single fertilization. Located in acrosomal vesicle; cell body; and plasma membrane. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4B nt-weight:700;'>C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 130474847 | 130557371 | Mouse | 136 | description | gene, protein-coding, VALIDATED [RefSeq] |
