Aim2 Gene Search Result

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3 records found for search term Aim2

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1622795	Aim2	absent in melanoma 2	Enables several functions, including identical protein binding activity; pattern recognition receptor activity; and signaling adaptor activity. Involved in several processes, including AIM2 inflammasome complex assembly; negative regulation of phosphatidylinosit ... (more) ol 3-kinase/protein kinase B signal transduction; and regulation of defense response. Acts upstream of or within cellular response to interferon-beta; positive regulation of inflammatory response; and protein maturation. Part of AIM2 inflammasome complex. Is active in cytoplasm; nucleus; and site of double-strand break. Is expressed in embryo. Orthologous to human AIM2 (absent in melanoma 2). [provided by Alliance of Genome Resources, Apr 2025]	1	173177105	173293606	Mouse	210	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
731729	Casp1	caspase 1	Enables cysteine-type endopeptidase activity. Involved in several processes, including AIM2 inflammasome complex assembly; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of interleukin-1 beta production. Acts upstream of ... (more) or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of cytokine production. Located in extracellular region. Part of IPAF inflammasome complex. Is active in cytosol. Is expressed in several structures, including forelimb mesenchyme; knee joint; oocyte; small intestine; and telencephalon. Orthologous to human CASP1 (caspase 1). [provided by Alliance of Genome Resources, Jul 2025]	9	5298517	5307281	Mouse	1168	description	gene, protein-coding, VALIDATED [RefSeq]
2295907	Gm12250	predicted gene 12250	Enables G protein activity and membrane destabilizing activity. Involved in several processes, including defense response to other organism; disruption of plasma membrane integrity in another organism; and positive regulation of defense response. Acts upstream of or within AIM2 ... (more) 00;'>AIM2 inflammasome complex assembly; non-canonical inflammasome complex assembly; and response to bacterium. Is active in symbiont cell surface. [provided by Alliance of Genome Resources, Apr 2025]	11	58074669	58081024	Mouse	29	description	gene, protein-coding, PROVISIONAL [RefSeq]