| 1344835 | ULK1 | unc-51 like autophagy activating kinase 1 | Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; protein phosphorylation; and regulation of autophagy. Located in bounding membrane of organelle; cytosol; and phag ophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 131894622 | 131923150 | Human | 389 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1602213 | ATG101 | autophagy related 101 | Enables identical protein binding activity. Involved in autophagosome assembly and negative regulation of cell population proliferation. Located in phagophore assembly site. Part of Atg1/ULK1 kinase complex. Biomarker of cholangiocarcinoma; colon cancer; and hep atocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 52065300 | 52077495 | Human | 82 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1345463 | SMCR8 | SMCR8-C9orf72 complex subunit | Enables GTPase activator activity; protein kinase binding activity; and protein kinase inhibitor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in negative regulation of gene expression; regulation of TOR signaling; and regulation of macroautophagy. Located in Atg1/... (more) an style='font-weight:700;'>ULK1 kinase complex; chromatin; and nucleoplasm. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 18315293 | 18328056 | Human | 106 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1321047 | TBC1D5 | TBC1 domain family member 5 | Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in several cellular components, including Atg1/ULK1 le='font-weight:700;'>ULK1 kinase complex; autophagosome; and cytoplasmic vesicle membrane. Part of retromer complex. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 17157162 | 17742631 | Human | 125 | description | gene, protein-coding, VALIDATED [RefSeq] |