| 733197 | TRPV1 | transient receptor potential cation channel subfamily V member 1 | Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008] | 17 | 3565446 | 3609411 | Human | 510 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 16563723 | AC027796.5 | novel transcript, sense intronic to TRPV1 | | | | | Human | | name | gene, lncrna |
| 16563487 | AC027796.1 | novel transcript, sense intronic to readthrough SHPK-TRPV1 | | | | | Human | | name | gene, lncrna |
| 3539788 | PIRT | phosphoinositide interacting regulator of transient receptor potential channels | Predicted to enable phosphatidylinositol bisphosphate binding activity and transmembrane transporter binding activity. Predicted to be involved in regulation of sensory perception of pain. Predicted to act upstream of or within behavioral response to pain; positive regulation of cation channel activ ity; and response to heat. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025] | 17 | 10822470 | 10838087 | Human | 36 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1317524 | SHPK | sedoheptulokinase | The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the p ossibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008] | 17 | 3608240 | 3636250 | Human | 136 | ensembl_full_name | gene, protein-coding, REVIEWED [RefSeq] |