| 1315706 | TRAF6 | TNF receptor associated factor 6 | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-fi nger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021] | 11 | 36483769 | 36510272 | Human | 420 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1348047 | TAX1BP1 | Tax1 binding protein 1 | This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein ma y also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] | 7 | 27739373 | 27829767 | Human | 155 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1606192 | TIFA | TRAF interacting protein with forkhead associated domain | This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecul ar interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018] | 4 | 112274537 | 112285904 | Human | 126 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1604218 | ZNF675 | zinc finger protein 675 | Enables ubiquitin protein ligase binding activity. Involved in negative regulation of osteoclast differentiation; negative regulation of signal transduction; and regulation of DNA-templated transcription. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resourc es, Apr 2025] | 19 | 23652801 | 23687212 | Human | 46 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1346082 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012] | 20 | 50081124 | 50115957 | Human | 102 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 7206876 | TRAF6P1 | TNF receptor associated factor 6 pseudogene 1 | | 10 | 59136427 | 59138382 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1319911 | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2 | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] | 6 | 149217926 | 149411607 | Human | 279 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1319782 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to I L-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | 6 | 90513579 | 90587072 | Human | 672 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351552 | OTUD7A | OTU deubiquitinase 7A | The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepat ocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016] | 15 | 31475398 | 31870673 | Human | 92 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605259 | PELI3 | pellino E3 ubiquitin protein ligase family member 3 | The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcrip t variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] | 11 | 66466327 | 66477337 | Human | 75 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1603527 | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3 | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in resp onse to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] | X | 30827442 | 30889254 | Human | 107 | description | gene, protein-coding, REVIEWED [RefSeq] |
