Tirap Gene Search Result

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6 records found for search term Tirap

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1322402	TIRAP	TIR domain containing adaptor protein	The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsi ... (more) ble for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]	11	126283093	126294933	Human	167	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
38660885	TIRAP-AS1	TIRAP antisense RNA 1		11	126294296	126304322	Human		symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
16560486	AP001318.1	novel transcript, antisense to TIRAP					Human		name	gene, lncrna
16560563	AP001318.2	novel transcript, antisense to DCPS and TIRAP					Human		name	gene, lncrna
1317929	TICAM2	TIR domain containing adaptor molecule 2	Enables molecular adaptor activity. Involved in several processes, including positive regulation of interleukin-18-mediated signaling pathway; regulation of cytokine production; and regulation of innate immune response. Located in endoplasmic reticulum; endosome; and phagocytic cup. Is active in end ... (more) osome membrane. [provided by Alliance of Genome Resources, Jul 2025]	5	115578496	115602479	Human	133	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
2837468	TMED7-TICAM2	TMED7-TICAM2 readthrough	This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes ... (more) a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]	5	115578496	115626036	Human	91	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]