Scrib Gene Search Result

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1321471	SCRIB	scribble planar cell polarity protein	This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other ... (more) proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]	8	143790925	143815773	Human	218	symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
733152	LLGL1	LLGL scribble cell polarity complex component 1	This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Ma ... (more) genis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]	17	18225635	18244875	Human	89	old_gene_name , name	gene, protein-coding, REVIEWED [RefSeq]
1353110	LLGL2	LLGL scribble cell polarity complex component 2	The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated ... (more) by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]	17	75525002	75575209	Human	121	old_gene_name , name	gene, protein-coding, REVIEWED [RefSeq]
731903	DLG1	discs large MAGUK scaffold protein 1	This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative sp ... (more) licing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018]	3	197042560	197299321	Human	434	old_gene_name	gene, protein-coding, REVIEWED [RefSeq]