| 1314509 | RNF6 | ring finger protein 6 | The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in th e transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008] | 13 | 26132115 | 26223085 | Human | 135 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 5131388 | RNF6P1 | ring finger protein 6 pseudogene 1 | | 21 | 39373763 | 39374421 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1602493 | MID2 | midline 2 | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this g ene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] | X | 107825735 | 107931637 | Human | 99 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1347564 | MKRN1 | makorin ring finger protein 1 | This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thoug ht to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] | 7 | 140453033 | 140479569 | Human | 81 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1321625 | MKRN2 | makorin ring finger protein 2 | This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory funct ion with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] | 3 | 12557087 | 12583713 | Human | 88 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322529 | MKRN3 | makorin ring finger protein 3 | The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008] | 15 | 23565674 | 23568044 | Human | 171 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1350230 | MKRN4P | makorin ring finger protein 4, pseudogene | Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025] | X | 40834254 | 40837807 | Human | 13 | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1349030 | MKRN9P | makorin ring finger protein 9, pseudogene | INTERACTS WITH tebuconazole | 12 | 87782885 | 87784711 | Human | 1 | old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 733503 | MNAT1 | MNAT1 component of CDK activating kinase | The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding differe nt isoforms have been found for this gene. [provided by RefSeq, Sep 2011] | 14 | 60734761 | 60969965 | Human | 107 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315966 | NEURL1 | neuralized E3 ubiquitin protein ligase 1 | Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025] | 10 | 103493705 | 103592546 | Human | 134 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1349943 | PCGF1 | polycomb group ring finger 1 | PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008] | 2 | 74505043 | 74507695 | Human | 89 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319563 | PEX10 | peroxisomal biogenesis factor 10 | This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger sy ndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 1 | 2403974 | 2413827 | Human | 339 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2303667 | NEURL1B | neuralized E3 ubiquitin protein ligase 1B | Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 172641263 | 172691540 | Human | 108 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
