| 1323649 | RNF20 | ring finger protein 20 | The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tum or suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012] | 9 | 101533853 | 101563344 | Human | 113 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1603826 | RNF207 | ring finger protein 207 | Enables Hsp70 protein binding activity and transmembrane transporter binding activity. Involved in positive regulation of gene expression. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 6206119 | 6221299 | Human | 99 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1603720 | RNF208 | ring finger protein 208 | Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 137220259 | 137223408 | Human | 55 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 21410035 | RNF207-AS1 | RNF207 antisense RNA 1 | | 1 | 6204840 | 6205780 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1346229 | COP1 | COP1 E3 ubiquitin ligase | Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 175944831 | 176207286 | Human | 82 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1314835 | RAPSN | receptor associated protein of the synapse | This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic si tes by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011] | 11 | 47437764 | 47449136 | Human | 939 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1349611 | RFWD3 | ring finger and WD repeat domain 3 | Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Located in nucleoplasm and site of double-str and break. Implicated in Fanconi anemia complementation group W. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 74621399 | 74666877 | Human | 246 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1601884 | TRAIP | TRAF interacting protein | This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear fac tor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008] | 3 | 49828601 | 49856564 | Human | 250 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1605231 | TRIML1 | tripartite motif family like 1 | The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the bla stocyst development stage. [provided by RefSeq, Sep 2016] | 4 | 188137229 | 188150767 | Human | 30 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352531 | ZNRF2 | zinc and ring finger 2 | Enables ubiquitin protein ligase activity. Involved in positive regulation of autophagosome-lysosome fusion. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. Is active in intracellular membrane-bounded organelle. [provided by Alliance o f Genome Resources, Apr 2025] | 7 | 30284597 | 30367689 | Human | 87 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1342950 | ZNRF3 | zinc and ring finger 3 | Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 22 | 28883572 | 29057488 | Human | 138 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1345671 | ZNRF4 | zinc and ring finger 4 | Enables ubiquitin protein ligase activity. Involved in negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 5455417 | 5456856 | Human | 50 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
