| 1319543 | RNF10 | ring finger protein 10 | The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008] | 12 | 120534356 | 120577588 | Human | 96 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1349364 | RNF103 | ring finger protein 103 | The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus wa s shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011] | 2 | 86603393 | 86623877 | Human | 112 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 6908270 | RNF10P1 | ring finger protein 10 pseudogene 1 | | 3 | 5068627 | 5069241 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5013867 | RNF103-CHMP3 | RNF103-CHMP3 readthrough | This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion protein that shares sequence ident ity with each individual gene product. [provided by RefSeq, Oct 2011] | 2 | 86503430 | 86721122 | Human | 105 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1322764 | TRIM47 | tripartite motif containing 47 | Enables ubiquitin protein ligase activity. Involved in protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 75874164 | 75878581 | Human | 108 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1343096 | TRIM48 | tripartite motif containing 48 | Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 55262155 | 55271114 | Human | 26 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1347364 | TRIM52 | tripartite motif containing 52 | Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and protein autoubiquitination. Located in cytoso l and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 181249062 | 181261143 | Human | 51 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1342742 | TRIM56 | tripartite motif containing 56 | Enables ubiquitin protein ligase activity. Involved in defense response to virus; positive regulation of signal transduction; and protein monoubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 101085481 | 101097967 | Human | 95 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1349912 | TRIM59 | tripartite motif containing 59 | Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 160435503 | 160449786 | Human | 130 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1318550 | TTC3 | tetratricopeptide repeat domain 3 | Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 21 | 37073254 | 37203118 | Human | 147 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1352913 | UHRF1 | ubiquitin like with PHD and ring finger domains 1 | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a ma jor role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014] | 19 | 4903080 | 4962154 | Human | 352 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1320632 | UHRF2 | ubiquitin like with PHD and ring finger domains 2 | This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012] | 9 | 6413199 | 6507054 | Human | 111 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1317575 | VPS11 | VPS11 core subunit of CORVET and HOPS complexes | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of ye ast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] | 11 | 119067818 | 119081972 | Human | 191 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2291791 | TTC3P1 | tetratricopeptide repeat domain 3 pseudogene 1 | INTERACTS WITH 4,4'-sulfonyldiphenol; cisplatin; lipopolysaccharide | X | 75740538 | 75743079 | Human | 7 | old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 38637878 | CHMP3-AS1 | CHMP3 and RNF103 antisense RNA 1 | | 2 | 86562070 | 86617449 | Human | | name | gene, ncrna, VALIDATED [RefSeq] |
| 1351348 | CHMP3 | charged multivesicular body protein 3 | This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits addit ional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010] | 2 | 86503430 | 86563443 | Human | 151 | description | gene, protein-coding, REVIEWED [RefSeq] |
