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Gene: TTC3 (tetratricopeptide repeat domain 3) Homo sapiens
Symbol: TTC3
Name: tetratricopeptide repeat domain 3
RGD ID: 1318550
Description: Exhibits ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Localizes to cytosol; nucleolus; and nucleoplasm; INTERACTS WITH 3-methylcholanthrene; 5-aza-2'-deoxycytidine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DCRR1; DKFZp686M0150; E3 ubiquitin-protein ligase TTC3; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3; RNF105; tetratricopeptide repeat protein 3; TPR repeat protein 3; TPR repeat protein D; TPRDIII
Mus musculus (house mouse) : Ttc3 (tetratricopeptide repeat domain 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ttc3 (tetratricopeptide repeat domain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ttc3 (tetratricopeptide repeat domain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TTC3 (tetratricopeptide repeat domain 3)
Canis lupus familiaris (dog) : TTC3 (tetratricopeptide repeat domain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ttc3 (tetratricopeptide repeat domain 3)
Sus scrofa (pig) : TTC3 (tetratricopeptide repeat domain 3)
Chlorocebus sabaeus (African green monkey) : TTC3 (tetratricopeptide repeat domain 3)
Heterocephalus glaber (naked mole-rat) : Ttc3 (tetratricopeptide repeat domain 3)
more info ...
Related Pseudogenes: TTC3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2137,073,226 - 37,203,112 (+)EnsemblGRCh38hg38GRCh38
GRCh382137,073,235 - 37,203,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372138,445,554 - 38,575,408 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,367,441 - 37,497,278 (+)NCBINCBI36hg18NCBI36
Build 342137,377,116 - 37,497,276NCBI
Celera2123,643,936 - 23,773,795 (+)NCBI
Cytogenetic Map21q22.13NCBI
HuRef2123,921,184 - 24,051,240 (+)NCBIHuRef
CHM1_12138,007,231 - 38,137,173 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TTC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318550
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.