| 1349944 | PTPN13 | protein tyrosine phosphatase non-receptor type 13 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008] | 4 | 86594315 | 86815161 | Human | 203 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1348546 | PRY | PTPN13 like Y-linked | This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more telomeric copy. [provided by RefSeq, Aug 2024] | Y | 22490397 | 22514637 | Human | 9 | old_gene_name , name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1349286 | PRY2 | PTPN13 like Y-linked 2 | This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more centromeric copy. [provided by RefSeq, Aug 2024] | Y | 22071706 | 22084875 | Human | 9 | old_gene_name , name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 2291812 | PRYP1 | PTPN13 like Y-linked pseudogene 1 | | Y | 17729799 | 17744540 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 2291811 | PRYP2 | PTPN13 like Y-linked pseudogene 2 | | Y | 18161364 | 18177051 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 2291810 | PRYP3 | PTPN13 like Y-linked pseudogene 3 | | Y | 23681340 | 23694681 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 2291809 | PRYP4 | PTPN13 like Y-linked pseudogene 4 | | Y | 25975395 | 25988736 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 10400078 | PRYP5 | PTPN13 like Y-linked pseudogene 5 | | Y | 18529258 | 18529723 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 10413234 | PRYP6 | PTPN13 like Y-linked pseudogene 6 | | Y | 18790609 | 18791151 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 1342986 | RBMY1E | RNA binding motif protein Y-linked family 1 member E | This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008] | Y | 21902177 | 21918032 | Human | 20 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1352327 | RBMY1F | RNA binding motif protein Y-linked family 1 member F | This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008] | Y | 22162885 | 22182923 | Human | 21 | description | gene, protein-coding, REVIEWED [RefSeq] |