| 737309 | PPARA | peroxisome proliferator activated receptor alpha | Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] | 22 | 46150526 | 46243756 | Human | 1512 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2304161 | MIRLET7BHG | MIRLET7B and MIRLET7A3 host gene | Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Implicated in lung cancer. [provided by Alliance of Genome Resources, Jul 2025] | 22 | 46085997 | 46113928 | Human | 26 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 16569830 | FP325332.1 | novel transcript, sense intronic to PPARA | | | | | Human | | name | gene, lncrna |
| 1350825 | ZNF286A | zinc finger protein 286A | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted t o be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 15699752 | 15720787 | Human | 64 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350671 | PPARGC1B | PPARG coactivator 1 beta | The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and t he regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] | 5 | 149730310 | 149857959 | Human | 210 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1342674 | PPARGC1A | PPARG coactivator 1 alpha | The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activit ies of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008] | 4 | 23792021 | 24472905 | Human | 1237 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1317349 | ADIPOR2 | adiponectin receptor 2 | The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidatio n and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008] | 12 | 1691070 | 1788674 | Human | 251 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1314765 | ALOXE3 | arachidonate epidermal lipoxygenase 3 | This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] | 17 | 8095900 | 8118916 | Human | 227 | description | gene, protein-coding, REVIEWED [RefSeq] |
