Mta1 Gene Search Result

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5 records found for search term Mta1

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
731516	MTA1	metastasis associated 1	This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many no ... (more) rmal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]	14	105419827	105470729	Human	202	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
16559319	MTA1-DT	MTA1 divergent transcript	INTERACTS WITH okadaic acid	14	105417581	105419739	Human	1	symbol , old_gene_name , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
16561252	AL928654.2	novel transcript, antisense to MTA1					Human		name	gene, lncrna
1315535	MTA2	metastasis associated 1 family member 2	This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family th ... (more) at encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]	11	62593214	62601865	Human	134	old_gene_name , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1316833	BLOC1S1	biogenesis of lysosomal organelles complex 1 subunit 1	BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplie ... (more) d by OMIM, Mar 2008]	12	55716046	55719703	Human	102	old_gene_name	gene, protein-coding, VALIDATED [RefSeq]